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Table 3 Accuracy of the association parameter as ln odds of being affected given two copies of the disease allele versus no copies for a sample size of 1,000 individuals

From: Genetic association tests: a method for the joint analysis of family and case-control data

  

Nuclear

Extended

Model*

 

RAND

ASC

RAND

ASC

FP-FP

Est

5.058

4.958

5.022

5.122

 

rMSE

0.2936

0.3936

0.3295

0.2296

FP-P

Est

5.074

5.018

5.034

5.048

 

rMSE

0.2777

0.3336

0.3176

0.3036

P-FP

Est

5.560

5.310

5.526

5.444

 

rMSE

0.1010

0.5696

0.3536

0.4357

P-P

Est

5.560

5.296

5.536

5.448

 

rMSE

0.3195

0.5836

0.3437

0.4316

  1. * Model indicates the variance components that were simulated followed by those included in the analysis model (F = familial and P = polygenic); Est is the average estimate across all replicates of that model; rMSE is the square root of the mean square error; ASC represents the analysis of an ascertained sample using ascertainment correction and RAND represents the analysis of a random sample without any such correction.
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Human Genomics

ISSN: 1479-7364