Figure 1
Biochemical diagram of folate metabolism (reproduced with permission from Reed et al.[14]). AICART, aminoimidazolecarboxamide ribonucleotide transferase; BHMT, betaine-homocysteine methyltransferase; CBS, cystathionine b-synthase; DHFR, dihydrofolate reductase; DNMT, DNA-methyltransferase; dTMP, thymidine monophosphate; FTD, 10-formyltetrahydrofolate dehydrogenase; FTS, 10-formyltetrahydrofolate synthase; GAR, glycinamide ribotid; G-NMT, glycine N-methyltransferase; HCOOH; formic acid; H2C = O, formaldehyde; HCY, homocysteine; MAT, methionine adenosyl transferase; MS, methionine synthase; MTCH, 5,10-methylenetetrahydrofolate cyclohydrolase; MTD, 5,10-methylenetetrahydrofolate dehydrogenase; MTHFR, 5,10-methylenetetrahydrofolate reductase; NE, nav-enzymatic; PGT, phosphoribosyl glycinamide transferase; SAH, S-adenosylhomocysteine; SAHH, SAH hydrolase; SAM, S-adenosylmethionine; SHMT, serine hydroxymethyltransferase; THF, tetrahydrofolate; 5m-THF, 5-methylTHF; 5,10-CH2-THF, 5,10-methyleneTHF; 10f-THF, 10-formylTHF; TS, thymidylate synthase.