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Figure 4 | Human Genomics

Figure 4

From: Use of pathway information in molecular epidemiology

Figure 4

Top-ranking topologies without incorporating priors: left, gene only; right, genes and exposures. With no priors, the two topologies have posterior probabilities 3.9 per cent and 2.3 per cent, respectively. Using a topology derived by hierarchical clustering of the A matrix from simulated data, the top-ranked gene-only topology was identical to that shown on the left, with posterior probability of 9.5 per cent. Using the GO topology shown in Figure 3, the same genes were included, but reordered as (((MTHR, SAHH), MTD), SHMT)with a posterior probability of 6.4 per cent.

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