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Table 7 Mendelian randomization estimates of the effect of homocysteine on disease risk

From: Use of pathway information in molecular epidemiology

Analysis

α in B|G

γ in Y|G

β in Y|B

Direct: Y|B

--

--

2.57 (0.22)

Mendelian randomisation

   

MTHFR

0.216 (0.079)

0.112 (0.142)

0.52 (0.68)

SAHH

20.633 (0.088)

-0.801 (0.175)

1.27 (0.33)

CBS

0.917 (0.074)

0.995 (0.166)

1.09 (0.20)

Single imputation

 

δ in B|G, Y

 

E(B|G)

R2 = 0.43

--

1.32 (0.16)

E(B|G, Y)|Y = 0

R2 = 0.71

1.33 (0.05)

1.28 (0.20)

E(B|G, Y = 0)

R2 = 0.43

--

1.31 (0.20)

Joint Bayesian

   
 

--

-0.04 (0.95)

1.92 (0.15)