Figure 3

Statistical parametric maps showing CMRglc reductions over a two-year follow-up interval. Compared with the baseline, reduced follow-up CMRglc was restricted to the frontal cortices in normal subjects with no family history of AD (top row, in green) and in those with an AD father (middle row, in blue), whereas follow-up CMRglc was reduced in inferior parietal, lateral and inferior temporal, posterior cingulate/precuneus and prefrontal cortex in normal individuals with a maternal history of AD (bottom row, in red). Figure shows the anterior, right lateral, superior and mid-sagittal views of a three-dimensional volume-rendered MRI.