Table 4 Mitochondrial DNA mutations and haplotypes associated with Parkinson's disease (PD)
From: Maternal transmission of Alzheimer's disease: Prodromal metabolic phenotype and the search for genes
mtDNA haplogroup or mutation | Hypothesised role | Reference |
|---|---|---|
Haplogroup J, K | Lower PD risk | Van der Walt et al. [142] |
UKJT haplogroup supercluster | Lower PD risk | Pyle et al. [143] |
JTIWX haplogroup supercluster | Higher PD and PD with dementia risk | Autere et al. [144] |
Haplogroup I, J, K | Decreased risk for PD but increased risk for PD with dementia | Autere et al. [144] |
mtDNA mutation: 10398G (J, K, I haplogroups) | Lower PD risk | Van der Walt et al.; [142] Autere et al. [144] |
mtDNA mutation: 9055A | Lower PD risk (only in women) | Van der Walt et al. [142] |
mtDNA mutation: 4216C (ND1 gene) | Increased PD risk | Kirchner et al. [145] |
mtDNA mutation: 4216C (ND1 gene) | No difference observed | Huerta et al. [146] |
mtDNA mutation: 4336 (tRNAglu) | More frequent in PD patients | Tan et al. [147] |