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Table 4 Mitochondrial DNA mutations and haplotypes associated with Parkinson's disease (PD)

From: Maternal transmission of Alzheimer's disease: Prodromal metabolic phenotype and the search for genes

mtDNA
haplogroup or
mutation
Hypothesised
role
Reference
Haplogroup J, K Lower PD risk Van der Walt et al. [142]
UKJT haplogroup
supercluster
Lower PD risk Pyle et al. [143]
JTIWX
haplogroup
supercluster
Higher PD and
PD with
dementia risk
Autere et al. [144]
Haplogroup I, J, K Decreased risk
for PD but
increased risk
for PD with
dementia
Autere et al. [144]
mtDNA
mutation:
10398G (J, K, I
haplogroups)
Lower PD risk Van der Walt et al.; [142]
Autere et al. [144]
mtDNA
mutation: 9055A
Lower PD risk
(only in women)
Van der Walt et al. [142]
mtDNA
mutation: 4216C
(ND1 gene)
Increased PD
risk
Kirchner et al. [145]
mtDNA
mutation: 4216C
(ND1 gene)
No difference
observed
Huerta et al. [146]
mtDNA
mutation: 4336
(tRNAglu)
More frequent in
PD patients
Tan et al. [147]