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Figure 5 | Human Genomics

Figure 5

From: From DNA to proteins via the ribosome: Structural insights into the workings of the translation machinery

Figure 5

Decoding and aa-tRNA incorporation. (A) Close-up view of the 30S subunit showing the decoding centre (DC) region in the presence of a cognate ternary complex. In the lower panel, the tRNA is computationally removed to show the tip of helix 44, in which A1492 and A1493 flip out as the result of a cognate codon-anticodon interaction. The resulting configuration is labelled with an asterisk. The orientation of the small subunit is shown as successive thumbnails on the left. (B) Arrangement of the P-site tRNA and ternary complex. The tRNA atomic models (displayed in ribbons) were obtained by fitting of the experimental cryo-EM densities (shown as transparent) with the X-ray-derived coordinates of the tRNAs by real-space refinement.

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Human Genomics

ISSN: 1479-7364