From: The clinical application of UGT1A1pharmacogenetic testing: Gene-environment interactions
Environmental factor | Summary | Ref. |
---|---|---|
Cruciferae intake | Homozygotes for the UGT1A1*28 showed decreased bilirubin concentrations after consuming cruciferous vegetables | 42 |
Citrus fruit intake | Women with two UGT1A1*28 alleles that consume citrus fruit may exhibit a higher activity of this gene than those who do not include it on their diet | 44 |
Fruit and vegetable diet | The intake of cruciferous vegetables, soy foods and citrus fruit seems to influence the decrease in bilirubin levels in women that are UGT1A1*28 homozygous | 45 |
Cigarette smoking | Smoking cigarettes can be related to a lower exposure to the metabolite of irinotecan, which can lead to less haematological toxicity | 41 |