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Table 3 Lifestyle factors that influence UGT1A1 activity

From: The clinical application of UGT1A1pharmacogenetic testing: Gene-environment interactions

Environmental factor

Summary

Ref.

Cruciferae intake

Homozygotes for the UGT1A1*28 showed decreased bilirubin concentrations after consuming cruciferous vegetables

42

Citrus fruit intake

Women with two UGT1A1*28 alleles that consume citrus fruit may exhibit a higher activity of this gene than those who do not include it on their diet

44

Fruit and vegetable diet

The intake of cruciferous vegetables, soy foods and citrus fruit seems to influence the decrease in bilirubin levels in women that are UGT1A1*28 homozygous

45

Cigarette smoking

Smoking cigarettes can be related to a lower exposure to the metabolite of irinotecan, which can lead to less haematological toxicity

41