Figure 2From: Hyperferritinaemia-cataract syndrome: Worldwide mutations and phenotype of an increasingly diagnosed genetic disorderPost-transcriptional control of ferritin synthesis by the IRP/IRE network. Iron depletion activates IRP-1 and -2 for binding to the IRE in the 5′-untranslated region of ferritin mRNA. This IRP-IRE interaction prevents translation of ferritin and eventually decreases ferritin protein levels. IRP, iron-regulatory protein.Back to article page