Table 2 Expression pattern, interacting co-factors, effect on gene expression and known functions of different KLFs.

KLF1

Erythroid and mast cells

P300/CBP, PCAF, SWI.SNF and mSin3A

Erythropoiesis, cell cycle

[25, 26]

KLF2

Lung, blood vessels, lymphocytes

WWP1

Adipogenesis, lung and blood vessel development, T-cell migration, monocyte activation

[27–30]

KLF3

Adipocytes, brain and erythroid tissue

CtBP2, FHL3

Adipogenesis

[31, 32]

KLF4

Gut, skin, cornea and several other epithelial tissues

HDAC, p300/CBP, b-catenin/TCF4, Oct4, Sox2, CtBP

Epithelial barrier formation, goblet cell development, adipogenesis, stem cell maintenance, control of cell proliferation, regulation of neuronal regeneration

[33–39]

KLF5

Gut, skin, lung, cornea and several other epithelial tissues

P53, HDAC1, PARP1, PIAS1

Cell growth, lung development, cardiac remodelling, stem cell maintenance

[40–45]

KLF6

Ubiquitous

HDAC3

Tumour suppressor

[46]

KLF7

Ubiquitous

MoKA

Cell proliferation, neuronal differentiation, olfactory bulb development

[47–51]

KLF8

Ubiquitous

CtBP2

Cell proliferation, epithelial to mesenchymal transition

[52–55]

KLF9

Ubiquitous

mSin3A

Neurite outgrowth, carcinogen metabolism, intestinal epithelial development

[56–58]

KLF10

Ubiquitous

mSin3A

Apoptosis, cell proliferation

[22, 59]

KLF11

Ubiquitous

mSin3A, p300

Cell proliferation

[60, 61]

KLF12

Brain, kidney, liver and lung

CtBP1

Cancer progression

[62, 63]

KLF13

Ubiquitous

mSin3A, p300, PCAF

Cell proliferation, carcinogen metabolism

[64, 65]

KLF14

Ubiquitous

mSin3A, HDAC2

Lipoprotein metabolism, basal cell carcinoma, TGF-β signalling

[66–68]

KLF15

Ubiquitous

Sp1, MEF2A

Cardiomyocyte hypertrophy, gluconeogenesis

[69–71]

KLF16

Ubiquitous

mSin3A

Carcinogen metabolism, cell cycle

[65, 72]

KLF17

Testis, brain and bone

Not known

Epithelial-mesenchyme transition

[73, 74]