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Table 2 Human IL classification.

From: Evolutionary divergence and functions of the human interleukin (IL) gene family

Group Genes Common features and structural Motifs
IL1-like IL1A, IL1B, IL1RN,
IL1F5, IL1F6, IL1F7,
IL1F8, IL1F9, IL1F10,
IL18, IL33
Fold rich in β-strands known as a β-trefoil
γ -chain utilising ('short-chain' class I) IL2, IL4, IL7, IL9,
IL15, IL21, TSPL
Four tightly packed α-helices known as 'four-helix bundle' motif; shorter core helices; receptor complex contains γc chain Subunit
IL4-like ('short-chain' class I) IL3, IL4, IL5, IL13,
CSF2
Four tightly packed α-helices known as 'four-helix bundle' motif; shorter core helices
IL6/12-like ('long-chain' class I) IL6, IL11, IL12A,
IL23A, IL27A, IL31,
CLCF1, CNTF, CTF1,
LIF, OSM, CSF3
Four tightly packed α-helices known as 'four-helix bundle' motif; longer core Helices
IL10-like (class II) IL10, IL19, IL20, IL22, IL24, IL26 'Bundled helix' structural motif containing six or seven stacked helices
IL28-like (class II) IL28A, IL28B, IL29 'Bundled helix' structural motif containing six or seven stacked helices
IL17-like IL17A, IL17B, IL17C, IL17D, IL25 (aka IL17E), IL17F Neurotrophin-like cysteine-knot fold
Non-classified IL8, TXLNA (aka IL14), IL16, IL32, IL34, CSF1 Varies
  1. The common features and structural motifs that were used for classification are listed in the right-hand column