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Table 4 Amino acid sequence homology between human IL proteins, as well as closely related cytokines.

From: Evolutionary divergence and functions of the human interleukin (IL) gene family

IL1-like           
  IL1A IL1B IL1RN IL18 IL1F5 IL1F6 IL1F7 IL1F8 IL1F9 IL1F10
IL1B 23.3%
(39.5%)
         
IL1RN 14.5%
(24.8%)
19.4%
(28.5%)
        
IL18 13.7%
(25.8%)
13.2%
(28.6%)
15.9%
(28.8%)
       
IL1F5 12.0%
(19.7%)
15.4%
(23.3%)
40.1%
(48.7%)
11.4%
(20.4%)
      
IL1F6 10.6%
(15.2%)
15.8%
(22.6%)
24.4%
(38.1%)
18.3%
(31.7%)
29.1%
(42.3%)
     
IL1F7 14.2%
(26.1%)
21.2%
(35.2%)
21.2%
(37.2%)
17.6%
(32.2%)
24.4%
(34.7%)
25.0%
(37.7%)
    
IL1F8 9.1%
(19.3%)
12.4%
(18.6%)
14.5%
(22.8%)
7.7%
(16.5%)
14.6%
(25.9%)
24.5%
(35.5%)
18.6%
(32.5%)
   
IL1F9 14.0%
(21.7%)
11.8%
(20.6%)
22.7%
(35.0%)
21.0%
(35.7%)
26.1%
(39.4%)
51.4%
(64.8%)
26.9%
(41.6%)
23.4%
(36.8%)
  
IL1F10 11.7%
(20.9%)
12.4%
(22.0%)
33.3%
(44.8%)
14.4%
(32.7%)
39.3%
(54.6%)
24.9%
(39.9%)
21.2%
(35.8%)
12.3%
(21.1%)
27.4%
(42.5%)
 
IL33 12.7%
(21.8%)
16.1%
(29.8%)
17.7%
(28.0%)
12.8%
(24.7%)
13.4%
(20.5%)
13.6%
(23.0%)
7.3%
(12.7%)
5.6%
(11.5%)
4.0%
(6.1%)
4.5%
(8.9%)
γ-chain utilising
  IL2 IL7 IL9 IL15 IL21      
IL7 5.7%
(10.4%)
         
IL9 16.9%
(29.2%)
17.6%
(28.0%)
        
IL15 18.2%
(33.7%)
16.7%
(27.3%)
17.3%
(28.1%)
       
IL21 19.5%
(33.5%)
15.0%
(29.2%)
17.9%
(30.0%)
21.9%
(38.8%)
      
TSPL 5.8%
(11.6%)
19.5%
(31.0%)
18.6%
(29.5%)
10.5%
(16.9%)
17.7%
(28.3%)
     
IL4-like           
  IL3 IL4 IL5 IL13       
IL4 22.1%
(30.4%)
         
IL5 23.5%
(34.2%)
21.4%
(33.0%)
        
IL13 24.7%
(38.7%)
23.6%
(32.5%)
23.9%
(35.2%)
       
CSF2 22.0%
(32.8%)
24.4%
(35.1%)
25.6%
(41.1%)
21.5%
(34.9%)
      
IL6/12-like           
  IL6 IL11 IL12A IL23A IL27A IL31 CLCF1 CNTF   
IL11 20.0%
(35.1%)
         
IL12A 16.4%
(28.9%)
3.5%
(5.4%)
        
IL23A 19.7%
(30.8%)
19.8%
(25.5%)
18.9%
(29.4%)
       
IL27A 19.8%
(31.7%)
22.1%
(32.0%)
4.4%
(5.8%)
16.2%
(25.6%)
      
IL31 15.7%
(28.8%)
10.8%
(16.0%)
7.6%
(15.2%)
21.0%
(32.9%)
12.7%
(18.0%)
     
CLCF1 17.0%
(29.3%)
21.5%
(28.5%)
15.0%
(23.9%)
13.3%
(20.1%)
20.3%
(29.7%)
10.2%
(16.4%)
    
CNTF 15.6%
(28.1%)
8.7%
(10.7%)
11.2%
(20.0%)
12.5%
(24.9%)
18.9%
(30.0%)
13.9%
(22.3%)
20.1%
(29.7%)
   
CTF1 3.8%
(8.5%)
24.4%
(30.7%)
3.6%
(5.6%)
16.3%
(21.9%)
5.1%
(8.1%)
12.3%
(19.0%)
21.8%
(33.3%)
20.7%
(33.2%)
  
IL10-like           
  IL10 IL19 IL20 IL22 IL24      
IL19 17.0%
(37.5%)
         
IL20 25.7%
(45.0%)
38.5%
(57.7%)
        
IL22 21.7%
(36.9%)
18.9%
(35.4%)
20.2%
(36.0%)
       
IL24 18.3%
(37.2%)
23.7%
(41.2%)
26.8%
(45.5%)
23.3%
(36.1%)
      
IL26 25.0%
(47.8%)
21.8%
(37.9%)
19.6%
(35.7%)
20.5%
(35.0%)
20.7%
(37.6%)
     
IL28-like           
  IL28A IL28B         
IL28B 94.0%
(95.5%)
         
IL29 66.5%
(73.7%)
68.8%
(75.1%)
        
IL17-like           
  IL17A IL17B IL17C IL17D IL25      
IL17B 25.9%
(37.6%)
         
IL17C 26.4%
(37.0%)
24.9%
(38.3%)
        
IL17D 20.3%
(24.5%)
26.1%
(35.2%)
22.3%
(27.5%)
       
IL25 25.0%
(40.0%)
18.3%
(27.2%)
26.3%
(35.7%)
21.2%
(30.3%)
      
IL17F 45.7%
(59.0%)
25.0%
(40.2%)
25.5%
(37.5%)
20.6%
(28.8%)
19.8%
(31.8%)
     
  1. Percentage identity and similarity (in parentheses) were determined using the EMBOSS Pairwise Alignment Algorithm www.ebi.ac.uk/Tools/emboss/align/ and non-redundant human protein sequences. The predominant, mature isoform sequences were used for proteins having multiple variants