Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of children

Table 3 Summary of strongest associations by phenotype (p-value cut-off with Bonferroni correction: 3.6 × 10^-4)

Gene	Chr. location(mB)	SNP	Phenotype	Model	Group	Uncorrected p-value
SPTBN1	2; 54.7M	rs3287	S_I	Recessive	All	5.8 × 10^-5
SPTBN1	2; 54.7M	rs3287	S_I	Genotypic	All	1.9 × 10^-4
HERC1	15; 61.7M	rs12439722	S_I	Genotypic	All	5.4 × 10^-4
TRPA1	8; 73.1M	rs1373302	AIRg	Dominant	All	9.7 × 10^-5
PLXNA4	7; 131.5M	rs2671110	AIRg	Recessive	AA	1.4 × 10^-4
HERC1	15; 61.7M	rs12439722	FI	Recessive	All	2.8 × 10^-4
HERC1	15; 61.7M	rs12439722	FI	Genotypic	All	1.4 × 10^-4
HERC1	15; 61.7M	rs12439722	HOMA-IR	Recessive	All	8.0 × 10^-4
HERC1	15; 61.7M	rs12439722	HOMA-IR	Genotypic	All	4.8 × 10^-4

Covariates: age, sex, Tanner stage, socioeconomic status, European admixture, Amerindian admixture, height, total fat (for acute insulin response to glucose, control for SI as well). SNP, single nucleotide polymorphism; SPTBN1, spectrin, beta, non-erythrocytic 1; PLXNA4, plexin A4.

ISSN: 1479-7364