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Table 4 Database comparisons for ease of use characteristics for finding variations causing inherited disease (mutations)

From: Difficulties in finding DNA mutations and associated phenotypic data in web resources using simple, uncomplicated search terms, and a suggested solution

Database

Mutations

found

Time

to

finda

(< 5)

CMCs

to find

(< 10)

Phenotype

found

Password

registration

not

required

Database

aim or

explanation

Clear

options

for

searching

Clear

site

layout

Recent

DB

update

(2008)

HGMD

*

*

*

*

  

*

*

e

OMIM

1b

*

*

*

*

*

*

*

*

dbSNPc

0b

NA

NA

NA

*

   

*

MutDB

*

*

*

*

*

*

*

*

 

MutView

0b

NA

NA

NA

*

 

*

*

 

GeneCards

0b

NA

NA

NA

*

*

*

d

*

GeneRev

0b

NA

NA

NA

*

 

*

*

 

dbGap

0b

NA

NA

NA

*

*

   

UniProt

*

*

*

*

*

*

*

*

*

Ensembl

3b

*

*

 

*

*

*

d

*

DGV

0b

NA

NA

NA

*

*

*

*

 

PAHdb

*

*

*

 

*

*

*

*

*

InSiGHT

*

*

*

*

*

*

*

d

*

BIC

*

*

*

*

 

*

*

*

 
  1. *Indicates compliance with column heading criteria.
  2. aFor the last mutation searched (thus allowing for an 'experience' factor).
  3. bActual number of mutations found.
  4. cIncluded for comparison, not a mutation database.
  5. dAlthough layout is relatively clear, many fields are included in these databases, making them complex to navigate initially.
  6. ePublic version only.
  7. NA, Not applicable (mutation not found).
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Human Genomics

ISSN: 1479-7364