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Figure 1 | Human Genomics

Figure 1

From: The human fatty acid-binding protein family: Evolutionary divergences and functions

Figure 1

Amino acid sequences of the human FABP family members 1-9 and 12 are demonstrated using the ClustalW2 multiple sequences alignment software program,[176]demonstrated in Jalview [177]. The colour of amino acids is determined by the default annotation created by the analysis of multiply aligned sequences (AMAS), where it allows the identification of functional residues by comparing subgroups of sequences arranged on a tree (http://www.compbio.dundee.ac.uk/Software/Amas/amas.html). Conservation between amino acids is demonstrated below the alignment, where yellow (value of 10) is 100 per cent conserved, and absence of bars (value of 0) represents zero conservation among the sequences at that point. The consensus sequence for the family is shown below the conservation annotation. Common among FAPBs is a three-element fingerprint domain, separated by motifs named FATTYACIDBP1-3 (Kyoto Encyclopedia of Genes and Genomes, PRINTS: PR00178). Each motif is identified by a black box outline. Characteristic structural elements of all iLBP family members, alpha helices and beta-sheets, are all shown in grey boxes. Amino acid sequences were obtained from the National Center for Biology Information (NCBI) website (www.ncbi.nlm.nih.gov/): FABP1 (GenBank: CAG46887.1), FABP2 (GenBank: AAH69617.1), FABP3 (GenBank: CAG33148.1), FABP4 (GenBank: CAG33184.1), FABP5 (NCBI Reference Sequence: NP_001435.1), FABP6 (GenBank: AAH22489.1), FABP7 (GenBank: CAG33338.1), FABP8 (NCBI Reference Sequence: NP_002668.1), FABP9 (NCBI Reference Sequence: NP_001073995.1) and FABP12 (NCBI Reference Sequence: NP_001098751.1).

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