Table 2 The proportion of mutations found within dinucleotides in the mutated stop codon-flanking pentanucleotides as compared with randomly generated HGMD controls
Dinucleotide | Occurrence of nonstop mutations in mutated sequence dataset (%) | Occurrence of random mutations within HGMD control sequences (%) | pvalue (after correction for multiple testing) |
|---|---|---|---|
AA | 25 (21.00) | 348 (20.57) | 0.907 |
AC | 6 (5.04) | 71 (4.196) | 0.636 |
AG | 18 (15.13) | 303 (17.91) | 0.534 |
AT | 16 (13.44) | 238 (14.066) | 1.0 |
CT | 23 (19.33) | 318 (18.79) | 0.903 |
GG | 1 (0.84) | 35 (2.07) | NA* |
GA | 32 (26.89) | 424 (25.06) | 0.663 |
GC | 1 (0.84) | 25 (1.48) | NA* |
GT | 21 (17.65) | 259 (15.31) | 0.511 |
TT | 10 (8.4) | 155 (9.16) | 1.0 |
TA | 36 (30.25) | 606 (35.82) | 0.235 |
TG | 49 (41.18) | 602 (35.58) | 0.236 |