Skip to main content

Table 4 Univariate association between demographic, genetic factors and risk of choroidal neovascular (CNV) disease

From: Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration

   Control
(822)
CNV
(1132)
Odds
(95% CI)
P-value
(Type 3)
c-statistic
Age (± SD)   76.4 (7.3) 76.5 (7.1) 1.001 (0.989-1.013) 0.87 0.50
Sex F 451 (55%) 696 (61%) 1.313 (1.094-1.576) 0.0034 0.53
  M 371 (45%) 436 (39%)    
rs10490924 GG 520 (63.3%) 340 (30%) 0.061 (0.04-0.093) < 0.0001 0.70
  GT 269 (32.7%) 505 (44.6%) 0.175 (0.114-0.268)   
  TT 26 (3.2%) 279 (24.6%)    
  (blank) 7 (0.9%) 8 (0.7%)    
rs1061170 CC 114 (13.9%) 394 (34.8%) 5.184 (3.934-6.831) < 0.0001 0.65
  CT 408 (49.6%) 535 (47.3%) 1.967 (1.575-2.456)   
  TT 294 (35.8%) 196 (17.3%)    
  (blank) 6 (0.7%) 7 (0.6%)    
rs10922153 GG 189 (23%) 498 (44%) 4.819 (3.64-6.382) < 0.0001 0.64
  GT 418 (50.9%) 515 (45.5%) 2.254 (1.738-2.922)   
  TT 214 (26%) 117 (10.3%)    
  (blank) 1 (0.1%) 2 (0.2%)    
rs12144939 GG 504 (61.3%) 930 (82.2%) 7.996 (3.842-16.639) < 0.0001 0.61
  GT 275 (33.5%) 192 (17%) 3.025 (1.432-6.391)   
  TT 39 (4.7%) 9 (0.8%)    
  (blank) 4 (0.5%) 1 (0.1%)    
rs1409153 AA 282 (34.3%) 192 (17%) 0.203 (0.154-0.267) < 0.0001 0.64
  AG 420 (51.1%) 539 (47.6%) 0.382 (0.3-0.487)   
  GG 118 (14.4%) 396 (35%)    
  (blank) 2 (0.2%) 5 (0.4%)    
rs1750311 AA 95 (11.6%) 53 (4.7%) 0.289 (0.202-0.415) < 0.0001 0.59
  AC 373 (45.4%) 411 (36.3%) 0.572 (0.472-0.692)   
  CC 346 (42.1%) 667 (58.9%)    
  (blank) 8 (1%) 1 (0.1%)    
rs2230199 CC 521 (63.4%) 621 (54.9%) 0.447 (0.289-0.691) < 0.0001 0.55
  CG 267 (32.5%) 428 (37.8%) 0.601 (0.385-0.94)   
  GG 30 (3.6%) 80 (7.1%)    
  (blank) 4 (0.5%) 3 (0.3%)    
rs2274700 AA 144 (17.5%) 48 (4.2%) 0.128 (0.09-0.183) < 0.0001 0.66
  AG 403 (49%) 378 (33.4%) 0.361 (0.296-0.441)   
  GG 268 (32.6%) 696 (61.5%)    
  (blank) 7 (0.9%) 10 (0.9%)    
rs2990510 GG 78 (9.5%) 183 (16.2%) 2.082 (1.541-2.813) < 0.0001 0.55
  GT 389 (47.3%) 544 (48.1%) 1.241 (1.023-1.506)   
  TT 355 (43.2%) 400 (35.3%)    
  (blank) (0%) 5 (0.4%)    
rs403846 AA 137 (16.7%) 445 (39.3%) 5.059 (3.848-6.652) < 0.0001 0.65
  AG 424 (51.6%) 521 (46%) 1.914 (1.515-2.418)   
  GG 257 (31.3%) 165 (14.6%)    
  (blank) 4 (0.5%) 1 (0.1%)    
rs641153 CC 644 (78.3%) 984 (86.9%) 2.674 (1.115-6.41) < 0.0001 0.55
  CT 159 (19.3%) 129 (11.4%) 1.42 (0.578-3.489)   
  TT 14 (1.7%) 8 (0.7%)    
  (blank) 5 (0.6%) 11 (1%)    
rs698859 AA 120 (14.6%) 235 (20.8%) 1.644 (1.257-2.15) 0.0012 0.54
  AG 403 (49%) 541 (47.8%) 1.127 (0.922-1.378)   
  GG 298 (36.3%) 355 (31.4%)    
  (blank) 1 (0.1%) 1 (0.1%)    
rs9332739 CC 2 (0.2%) 1 (0.1%) 0.348 (0.032-3.85) 0.0022 0.52
  CG 72 (8.8%) 55 (4.9%) 0.532 (0.37-0.766)   
  GG 745 (90.6%) 1069 (94.4%)    
  (blank) 3 (0.4%) 7 (0.6%)    
  1. CI, confidence interval