Table 4 Univariate association between demographic, genetic factors and risk of choroidal neovascular (CNV) disease
| Â | Â | Control (822) | CNV (1132) | Odds (95% CI) | P-value (Type 3) | c-statistic |
|---|---|---|---|---|---|---|
Age (± SD) |  | 76.4 (7.3) | 76.5 (7.1) | 1.001 (0.989-1.013) | 0.87 | 0.50 |
Sex | F | 451 (55%) | 696 (61%) | 1.313 (1.094-1.576) | 0.0034 | 0.53 |
| Â | M | 371 (45%) | 436 (39%) | Â | Â | Â |
rs10490924 | GG | 520 (63.3%) | 340 (30%) | 0.061 (0.04-0.093) | < 0.0001 | 0.70 |
| Â | GT | 269 (32.7%) | 505 (44.6%) | 0.175 (0.114-0.268) | Â | Â |
| Â | TT | 26 (3.2%) | 279 (24.6%) | Â | Â | Â |
| Â | (blank) | 7 (0.9%) | 8 (0.7%) | Â | Â | Â |
rs1061170 | CC | 114 (13.9%) | 394 (34.8%) | 5.184 (3.934-6.831) | < 0.0001 | 0.65 |
| Â | CT | 408 (49.6%) | 535 (47.3%) | 1.967 (1.575-2.456) | Â | Â |
| Â | TT | 294 (35.8%) | 196 (17.3%) | Â | Â | Â |
| Â | (blank) | 6 (0.7%) | 7 (0.6%) | Â | Â | Â |
rs10922153 | GG | 189 (23%) | 498 (44%) | 4.819 (3.64-6.382) | < 0.0001 | 0.64 |
| Â | GT | 418 (50.9%) | 515 (45.5%) | 2.254 (1.738-2.922) | Â | Â |
| Â | TT | 214 (26%) | 117 (10.3%) | Â | Â | Â |
| Â | (blank) | 1 (0.1%) | 2 (0.2%) | Â | Â | Â |
rs12144939 | GG | 504 (61.3%) | 930 (82.2%) | 7.996 (3.842-16.639) | < 0.0001 | 0.61 |
| Â | GT | 275 (33.5%) | 192 (17%) | 3.025 (1.432-6.391) | Â | Â |
| Â | TT | 39 (4.7%) | 9 (0.8%) | Â | Â | Â |
| Â | (blank) | 4 (0.5%) | 1 (0.1%) | Â | Â | Â |
rs1409153 | AA | 282 (34.3%) | 192 (17%) | 0.203 (0.154-0.267) | < 0.0001 | 0.64 |
| Â | AG | 420 (51.1%) | 539 (47.6%) | 0.382 (0.3-0.487) | Â | Â |
| Â | GG | 118 (14.4%) | 396 (35%) | Â | Â | Â |
| Â | (blank) | 2 (0.2%) | 5 (0.4%) | Â | Â | Â |
rs1750311 | AA | 95 (11.6%) | 53 (4.7%) | 0.289 (0.202-0.415) | < 0.0001 | 0.59 |
| Â | AC | 373 (45.4%) | 411 (36.3%) | 0.572 (0.472-0.692) | Â | Â |
| Â | CC | 346 (42.1%) | 667 (58.9%) | Â | Â | Â |
| Â | (blank) | 8 (1%) | 1 (0.1%) | Â | Â | Â |
rs2230199 | CC | 521 (63.4%) | 621 (54.9%) | 0.447 (0.289-0.691) | < 0.0001 | 0.55 |
| Â | CG | 267 (32.5%) | 428 (37.8%) | 0.601 (0.385-0.94) | Â | Â |
| Â | GG | 30 (3.6%) | 80 (7.1%) | Â | Â | Â |
| Â | (blank) | 4 (0.5%) | 3 (0.3%) | Â | Â | Â |
rs2274700 | AA | 144 (17.5%) | 48 (4.2%) | 0.128 (0.09-0.183) | < 0.0001 | 0.66 |
| Â | AG | 403 (49%) | 378 (33.4%) | 0.361 (0.296-0.441) | Â | Â |
| Â | GG | 268 (32.6%) | 696 (61.5%) | Â | Â | Â |
| Â | (blank) | 7 (0.9%) | 10 (0.9%) | Â | Â | Â |
rs2990510 | GG | 78 (9.5%) | 183 (16.2%) | 2.082 (1.541-2.813) | < 0.0001 | 0.55 |
| Â | GT | 389 (47.3%) | 544 (48.1%) | 1.241 (1.023-1.506) | Â | Â |
| Â | TT | 355 (43.2%) | 400 (35.3%) | Â | Â | Â |
| Â | (blank) | (0%) | 5 (0.4%) | Â | Â | Â |
rs403846 | AA | 137 (16.7%) | 445 (39.3%) | 5.059 (3.848-6.652) | < 0.0001 | 0.65 |
| Â | AG | 424 (51.6%) | 521 (46%) | 1.914 (1.515-2.418) | Â | Â |
| Â | GG | 257 (31.3%) | 165 (14.6%) | Â | Â | Â |
| Â | (blank) | 4 (0.5%) | 1 (0.1%) | Â | Â | Â |
rs641153 | CC | 644 (78.3%) | 984 (86.9%) | 2.674 (1.115-6.41) | < 0.0001 | 0.55 |
| Â | CT | 159 (19.3%) | 129 (11.4%) | 1.42 (0.578-3.489) | Â | Â |
| Â | TT | 14 (1.7%) | 8 (0.7%) | Â | Â | Â |
| Â | (blank) | 5 (0.6%) | 11 (1%) | Â | Â | Â |
rs698859 | AA | 120 (14.6%) | 235 (20.8%) | 1.644 (1.257-2.15) | 0.0012 | 0.54 |
| Â | AG | 403 (49%) | 541 (47.8%) | 1.127 (0.922-1.378) | Â | Â |
| Â | GG | 298 (36.3%) | 355 (31.4%) | Â | Â | Â |
| Â | (blank) | 1 (0.1%) | 1 (0.1%) | Â | Â | Â |
rs9332739 | CC | 2 (0.2%) | 1 (0.1%) | 0.348 (0.032-3.85) | 0.0022 | 0.52 |
| Â | CG | 72 (8.8%) | 55 (4.9%) | 0.532 (0.37-0.766) | Â | Â |
| Â | GG | 745 (90.6%) | 1069 (94.4%) | Â | Â | Â |
| Â | (blank) | 3 (0.4%) | 7 (0.6%) | Â | Â | Â |