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Table 9 Comparison of models containing different numbers of single nucleotide polymorphisms (SNPs)

From: Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration

Model Reported
AUC
Current
study
training
AUC
Significance
to 13 SNP
SCMM
training
Current
study
validation
AUC
Significance
to 13 SNP
SCMM
validation
Three-SNP
(Jakobsdottir[41])
0.79 0.77 <0.0001 0.77 <0.001
Six-SNP
(Seddon[42])
0.82a 0.81 <0.01 0.79 <0.05
Nine-SNP
(SCMM)
NA 0.81 <0.01 0.79 nsb
13-SNP
(SCMM)
NA 0.82 -- 0.80 --
  1. AUC, area under the curve; SCMM, Sequenom Center for Molecular Medicine. aAUC value based on model with six SNPs and multiple environmental risk variables (eg baseline grade, education status, BMI, smoking history). bns: not significant (p > 0.05).