Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration

Table 9 Comparison of models containing different numbers of single nucleotide polymorphisms (SNPs)

Model	Reported AUC	Current study training AUC	Significance to 13 SNP SCMM training	Current study validation AUC	Significance to 13 SNP SCMM validation
Three-SNP (Jakobsdottir[41])	0.79	0.77	<0.0001	0.77	<0.001
Six-SNP (Seddon[42])	0.82^a	0.81	<0.01	0.79	<0.05
Nine-SNP (SCMM)	NA	0.81	<0.01	0.79	ns^b
13-SNP (SCMM)	NA	0.82	--	0.80	--

AUC, area under the curve; SCMM, Sequenom Center for Molecular Medicine. ^aAUC value based on model with six SNPs and multiple environmental risk variables (eg baseline grade, education status, BMI, smoking history). ^bns: not significant (p > 0.05).

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