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Table 3 Clinico-epidemiological variables of the 86 CRC patients versus 47 hypermethylated phenotypes of APC (1A and 1B promoter) gene

From: Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population

Variable Total
n= 86
Mutantsa
n= 11
(12.79%)
Methylatedb
n= 47
(54.65%)
p
valuec
Age group     
≤ 60 52 (60.5%) 5 20 < 0.05
> 60 34 (39.5%) 6 27  
Gender     
Female 37 (43.0%) 4 19 0.85
Male 49 (67.0%) 7 28  
Dwelling     
Urban 27 (31.4%) 5 17 0.70
Rural 59 (68.6%) 6 30  
Tumour location     
Colon 36 (41.9%) 8 29 < 0.05
Rectum 50 (58.1%) 3 18  
Nodal status     
Involved 48 (55.8%) 6 38 < 0.05
Not Involved 38 (44.2%) 5 9  
Tumour grade     
A + B 38 (44.2%) 5 9 < 0.05
C + D 48 (55.8%) 6 38  
Smoking status     
Never 31 (36.0%) 4 14 0.56
Ever 55 (64.0%) 7 33  
Bleeding PR/Constipation     
No 26 (30.2%) 2 16 0.69
Yes 60 (69.8%) 9 31  
Pesticide exposure     
Never 33 (38.4%) 3 19 0.85
Ever 53 (61.6%) 8 28  
  1. aOther than G > A transition at codon 1492 of APC.
  2. bEither 1A or 1B promoter hypermethylation.
  3. cFisher's two-tailed test for hypermethylation status of APC.