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Table 3 Clinico-epidemiological variables of the 86 CRC patients versus 47 hypermethylated phenotypes of APC (1A and 1B promoter) gene

From: Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population

Variable

Total

n= 86

Mutantsa

n= 11

(12.79%)

Methylatedb

n= 47

(54.65%)

p

valuec

Age group

    

≤ 60

52 (60.5%)

5

20

< 0.05

> 60

34 (39.5%)

6

27

 

Gender

    

Female

37 (43.0%)

4

19

0.85

Male

49 (67.0%)

7

28

 

Dwelling

    

Urban

27 (31.4%)

5

17

0.70

Rural

59 (68.6%)

6

30

 

Tumour location

    

Colon

36 (41.9%)

8

29

< 0.05

Rectum

50 (58.1%)

3

18

 

Nodal status

    

Involved

48 (55.8%)

6

38

< 0.05

Not Involved

38 (44.2%)

5

9

 

Tumour grade

    

A + B

38 (44.2%)

5

9

< 0.05

C + D

48 (55.8%)

6

38

 

Smoking status

    

Never

31 (36.0%)

4

14

0.56

Ever

55 (64.0%)

7

33

 

Bleeding PR/Constipation

    

No

26 (30.2%)

2

16

0.69

Yes

60 (69.8%)

9

31

 

Pesticide exposure

    

Never

33 (38.4%)

3

19

0.85

Ever

53 (61.6%)

8

28

 
  1. aOther than G > A transition at codon 1492 of APC.
  2. bEither 1A or 1B promoter hypermethylation.
  3. cFisher's two-tailed test for hypermethylation status of APC.