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Table 4 Nature of APC mutation cluster region mutations in 11 CRC patients from the Kashmir valley

From: Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population

Patient ID Mutationa Amino acid change Affected codon Effect
A6 TTA > TAA Leu > Stop 1277 NS
A8 ACCAA > ACA Del CA 1448/49 FS
A9 TTA > GTA Leu > Val 1489 MS
A22 AGT > ATT Ser > Ile 1494 MS
A25 AGA > AGT Arg > Ser 1336 MS
A27 AGT > ATT Ser > Ile 1494 MS
A28 TTA > TAA Leu > Stop 1277 NS
A31 TAAAAGAAAAG > TAAAAGA Del AAAAG 1307/08/09 FS
A33 TAAAAG > TAAG Del AA 1307/08 FS
A37 AAG > TAG Lys > Stop 1449 NS
A77 ATG > ATAG Ins A 1525 FS
XXb ACG > ACA Thr > Thr 1492 S
  1. aMutated, deleted or inserted nucleotide underlined.
  2. bXX refers to any general tumour sample.
  3. Abbreviations: MS, missense mutation; NS, nonsense mutation; S, silent mutation; FS, Frameshift mutation.