Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population

Table 4 Nature of APC mutation cluster region mutations in 11 CRC patients from the Kashmir valley

Patient ID	Mutation^a	Amino acid change	Affected codon	Effect
A6	TTA > TAA	Leu > Stop	1277	NS
A8	ACCAA > ACA	Del CA	1448/49	FS
A9	TTA > GTA	Leu > Val	1489	MS
A22	AGT > ATT	Ser > Ile	1494	MS
A25	AGA > AGT	Arg > Ser	1336	MS
A27	AGT > ATT	Ser > Ile	1494	MS
A28	TTA > TAA	Leu > Stop	1277	NS
A31	TAAAAGAAAAG > TAAAAGA	Del AAAAG	1307/08/09	FS
A33	TAAAAG > TAAG	Del AA	1307/08	FS
A37	AAG > TAG	Lys > Stop	1449	NS
A77	ATG > ATAG	Ins A	1525	FS
XX^b	ACG > ACA	Thr > Thr	1492	S

^aMutated, deleted or inserted nucleotide underlined.
^bXX refers to any general tumour sample.
Abbreviations: MS, missense mutation; NS, nonsense mutation; S, silent mutation; FS, Frameshift mutation.

ISSN: 1479-7364