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Table 5 PCMs (disease-causing and disease-related) with significantly different genotype frequencies in different HapMap populations

From: Cross-comparison of the genome sequences from human, chimpanzee, Neanderthal and a Denisovan hominin identifies novel potentially compensated mutations

      Asian European African Pair-wise FST (pvalue)
Gene rs HGMD
Acc
WT PCM fWT n fWT n fWT n Asian-African European-African Asian-European
SLC24A5 rs1426654 CM054862 A G 0.01 178 1.00 116 0.03 120 -0.001 (0.8490) 0.974 (0.0054) 0.987 (0.0010)
TP53BP1* rs2602141 CM067476 T G 0.52 176 0.69 120 0.00 120 0.470 (0.2830) 0.689 (0.0489) 0.054 (0.5701)
CAPN3* rs1801449 CM099258 G A 0.91 178 0.94 120 0.23 120 0.653 (0.2234) 0.143 (0.3877) 0.680 (0.0026)
TP53BP1* rs560191 CM067475 G C 0.52 178 0.69 120 0.00 120 0.475 (0.2981) 0.689 (0.0489) 0.051 (0.5536)
ADH1B rs1229984 CM890003 T C 0.75 178 0.00 120 0.00 118 0.715 (0.1576) NA (NA) 0.717 (0.0197)
ENPP1* rs1044498 CM993455 A C 0.94 180 0.87 118 0.00 120 0.927 (0.0314) 0.873 (0.0110) 0.020 (0.6004)
  1. *Previously reported by Zhang et al.[10]
  2. rs: reference number, dbSNP, WT: wild type, fWT: frequency of the wild-type allele, NA: Not applicable.