The human sirtuin family: Evolutionary divergences and functions

Table 1 List of the members of the sirtuin family in humans

Gene name	Intracellular location	Functional activity	MW (kDa)	AA	Active domain (AA)	Chromosomal location
SIRT1	Nucleus and cytoplasm	Deacetylase	81.7	747	244-498	10q21.3
SIRT2	Cytoplasm	Deacetylase	41.5	389	65-340	19q13.3
SIRT3	Mitochondria	Deacetylase	43.6	399	126-382	11p15.5
SIRT4	Mitochondria	ADP-ribosyl transferase	35.2	314	45-314	12q
SIRT5	Mitochondria	Deacetylase	33.9	310	41-309	6p23
SIRT6	Nucleus	Deacetylase/ADP-ribosyl transferase	39.1	355	35-274	19p13.1
SRT7	Nucleolus	Deacetylase	44.9	400	90-331	17q25

For each member, cellular localisation, major functional activity, molecular weight (MW), total number of amino acids (AA), active domain and chromosomal location is listed.

ISSN: 1479-7364