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Table 3 Genotype frequencies of CYP2E1 polymorphism in cases and controls

From: Role of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population

CYP2E1genotype

Cases

(n= 86)

Controls

(n= 160)

OR (95% CI); χ2a; pvalueb

χ2; pvalue

(overall)

RsaI

    

c1/c1 (wild-type)

46 (53.5%)

112 (70.0%)

1.0 (ref)

6.81; 0.03

c1/c2

15 (17.4%)

20 (12.5%)

1.8 (0.86-3.87); 0.11; 0.15

 

c2/c2 (variant)

25 (29.1%)

28 (17.5%)

2.17 (1.14-4.11); 0.01; 0.01

 

c1/c2 or c2/c2

40 (46.5%)

48 (30.0%)

2.02 (1.17-3.48); 0.009; 0.01

 

96-bp insertion

    

i/i (non-insertion)

55 (63.9%)

130 (81.3%)

1.0 (ref)

12.1; 0.002

i/I

19 (22.1%)

12 (7.5%)

3.74 (1.7-8.23); 0.0006; 0.0009

 

I/I (insertion)

12 (13.9%)

18 (11.3%)

1.57 (0.79-3.49); 0.25; 0.29

 

i/I or I/I

31 (36.0%)

30 (18.8%)

2.44 (1.31-4.41); 0.003; 0.003

 
  1. a Pearson value; bFisher exact value. Significant p values are shown in bold.