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Table 1 Single factor analysis of epidemiological factors using conditional logistic regression

From: Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration

   

Distribution of continuous variables (if applicable)

Risk factor

Odds ratio (95% confidence interval)

p-Value

Average

Min

Max

Vitamin D supplements for ≥6 months

0.862 (0.505-1.472)

0.5866

   

Multivitamin supplements for ≥6 months

0.667 (0.237-1.873)

0.4417

   

Serum 25(OH)D level (ng/ml)

0.973 (0.934-1.013)

0.1859

26.10

5.10

67.30

Blue eyes

1.064 (0.654-1.731)

0.8039

   

Green eyes

1.000 (0.573-1.744)

1.0000

   

Brown eyes

0.966 (0.579-1.613)

0.8960

   

Skin cancer

1.050 (0.570-1.933)

0.8762

   

Sun exposure now 1†

1.071 (0.517-2.220)

0.8528

   

Sun exposure now 2†

1.350 (0.757-2.407)

0.3090

   

Sun exposure now 3†

0.929 (0.545-1.584)

0.7856

   

Sun exposure now 4†

0.750 (0.407-1.382)

0.3562

   

Sun exposure now 1 or 2†

1.381 (0.788-2.421)

0.2600

   

Sun exposure 15 years ago 1†

0.955 (0.525-1.736)

0.8788

   

Sun exposure 15 years ago 2†

1.333 (0.831-2.141)

0.2336

   

Sun exposure 15 years ago 3†

1.045 (0.583-1.876)

0.8815

   

Sun exposure 15 years ago 4†

0.375 (0.147-0.958)

0.0405

   

Sun exposure 15 years ago 1 or 2†

1.409 (0.816-2.433)

0.2186

   

Year UV index (TUV)‡

0.115 (0.031-0.432)

0.0013

5.33

4.37

7.49

Year UV-A (TUV)‡

0.619 (0.463-0.829)

0.0013

40.69

36.16

50.58

Year UV-B (TUV)‡

0.009 (0.008-0.010)

0.0013

1.01

0.84

1.41

Year UV index (EPA)§

0.104 (0.020-0.541)

0.0071

4.13

1.00

10.00

  1. Abbreviations: EPA, Environmental Protection Agency; Min, minimum; Max, maximum; 25(OH)D, 25-hydroxyvitamin D.
  2. †Self-reported sun exposure 1: spends most of the day outside; self-reported sun exposure 2: spends most of free time outside; self-reported sun exposure 3: occasionally spends a day in the sun; self-reported sun exposure 4: almost never outside.
  3. ‡As calculated using data from the TUV calculator http://cprm.acd.ucar.edu/Models/TUV/Interactive_TUV/.
  4. §As calculated using data from the US EPA SunWise Program http://www.epa.gov/sunwise1/doc/uvimonth.html.