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Table 3 Family-based association test analysis of individual CYP27A1, CYP27B1, VDR and CYP24A1 SNPs in discovery cohort

From: Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration

Marker

Allele

Frequency

Informative families

Z score

p-Value

CYP27A1

     

rs7594289

G

0.428

51

-0.808

0.4189

rs7566656

A

0.485

60

1.179

0.2383

CYP27B1

     

rs8176345

A

0.030

< 2

0.000

1.0000

rs4646536

C

0.324

< 2

0.000

1.0000

VDR

     

rs4516035

G

0.443

47

1.116

0.2643

rs7299460

A

0.262

36

1.333

0.1824

rs10783219

A

0.361

42

-0.630

0.5287

rs7136534

A

0.238

35

1.622

0.1048

rs11574026

T

0.120

23

0.626

0.5316

rs11574027

T

0.017

2

1.414

0.1573

rs4237855

T

0.490

47

-0.329

0.7419

rs4328262

A

0.568

49

0.956

0.3390

rs11168287

C

0.485

56

-0.570

0.5688

rs4760648

A

0.447

52

-0.640

0.5221

rs2853564

C

0.395

46

0.000

1.0000

rs2238136

A

0.283

43

-1.000

0.3173

rs2254210

T

0.369

54

0.843

0.3994

rs10735810

T

0.374

48

0.739

0.4602

rs10875693

A

0.679

46

0.000

1.0000

rs2239186

C

0.248

44

-0.137

0.8907

rs3782905

G

0.282

34

-0.152

0.8788

rs3819545

C

0.427

54

0.226

0.8208

rs2189480

C

0.593

45

-1.807

0.0707

rs12721370

T

0.112

15

1.414

0.1573

rs12717991

G

0.564

51

0.000

1.0000

rs2239179

G

0.349

47

-0.911

0.3621

rs2283342

C

0.205

38

-0.302

0.7630

rs2107301

T

0.340

46

0.405

0.6858

rs2239182

G

0.420

46

0.788

0.4308

rs11574077

G

0.028

10

-0.632

0.5271

rs11168267

T

0.116

17

0.728

0.4669

rs7975128

T

0.333

45

0.132

0.8946

rs1544410

A

0.337

46

-0.640

0.5221

rs7975232

T

0.494

52

0.239

0.8111

rs731236

C

0.320

45

-0.775

0.4386

rs3847987

T

0.150

28

1.029

0.3035

CYP24A1

     

rs2248359

A

0.425

49

-0.611

0.5413

rs6022999

C

0.250

42

-1.089

0.2763

rs2585428

A

0.441

56

-0.342

0.7324

rs2245153

G

0.201

48

1.089

0.2763

rs4809960

G

0.229

51

1.192

0.2332

rs4809959

C

0.500

46

0.122

0.9028

rs2181874

T

0.247

45

-1.633

0.1025

rs3787557

G

0.144

40

1.265

0.2059

rs3787555

T

0.263

42

1.260

0.2076

rs3787554

T

0.065

20

0.209

0.8348

rs4809958

C

0.128

25

1.134

0.2568

rs2762939

G

0.275

36

-0.816

0.4142

rs6068816

A

0.079

22

0.000

1.0000

rs6127118

T

0.157

22

2.132

0.0330

rs2209314

G

0.256

43

-1.387

0.1655

rs1570669

C

0.335

45

0.630

0.5287

rs927650

G

0.511

44

-0.391

0.6961

rs2762934

T

0.156

29

-2.535

0.0112

rs6097807

C

0.241

50

-1.131

0.2579

rs6068810

A

0.059

17

0.728

0.4669