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Table 1 Analysis of molecular heterogeneity with respect to NF1 , TP53 , RB1 , CDKN2A , and PTEN in 10 MPNSTs

From: Molecular heterogeneity in malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1

Tumor Tumor number Tumor section Tumor subsection NF1 TP53 RB1 PTEN CDKN2A
1 T196.22 A 1 LOH LOH LOH LOH LOH
  2 LOH LOH LOH LOH LOH
  3 LOH LOH 50% LOH LOH LOH
  4 1 2 1 2 1 2 1 2 1 2
  5 LOH LOH 50% LOH LOH LOH
  6 LOH LOH LOH LOH LOH
  7 LOH LOH LOH LOH LOH
  8 LOH LOH 50% LOH 50% LOH LOH
  9 1 2 LOH 1 2 LOH LOH
  10 1 2 LOH 1 2 LOH LOH
B 1 LOH 50% LOH 50% LOH 50% LOH 1 2
  2 LOH 50% LOH 50% LOH 50% LOH 1 2
  3 LOH 50% LOH 50% LOH 50% LOH 1 2
  4 LOH 50% LOH 50% LOH 50% LOH 1 2
  5 50% LOH 50% LOH 50% LOH 50% LOH 1 2
  6 LOH 50% LOH 50% LOH 50% LOH 1 2
  7 LOH 50% LOH 50% LOH 50% LOH 1 2
  8 LOH 50% LOH 50% LOH 50% LOH 1 2
  9 LOH 50% LOH 50% LOH 50% LOH 1 2
  10 LOH 50% LOH 50% LOH 50% LOH 1 2
C 1 LOH LOH 50% LOH LOH 1 2
2 LOH LOH 50% LOH LOH 1 2
3 LOH LOH 50% LOH LOH 1 2
4 LOH LOH 50% LOH LOH 1 2
5 1 2 LOH 1 2 50% LOH 50% LOH
6 LOH LOH 50% LOH LOH 50% LOH
7 LOH LOH 50% LOH LOH 50% LOH
8 LOH LOH 50% LOH LOH 50% LOH
9 LOH LOH 50% LOH LOH 50% LOH
10 LOH LOH 50% LOH LOH 50% LOH
D 1 LOH LOH 50% LOH LOH 50% LOH
2 LOH LOH 50% LOH 50% LOH 1 2
3 LOH LOH 50% LOH LOH LOH
4 LOH LOH 50% LOH LOH LOH
5 LOH LOH 50% LOH LOH LOH
6 LOH LOH 50% LOH LOH LOH
7 LOH LOH 50% LOH LOH LOH
8 LOH LOH 50% LOH LOH LOH
9 LOH LOH 50% LOH LOH LOH
10 LOH LOH 50% LOH LOH LOH
E 1 LOH 1 2 1 2 1 2 1 2
2 LOH 1 2 1 2 50% LOH 1 2
3 50% LOH 1 2 1 2 1 2 1 2
4 LOH 1 2 1 2 50% LOH 1 2
5 1 2 1 2 1 2 0% 1 2
6 50% LOH 1 2 1 2 50% LOH 1 2
7 50% LOH 1 2 1 2 0% 1 2
8 LOH 1 2 1 2 1 2 1 2
9 LOH 1 2 1 2 1 2 1 2
10 LOH 1 2 1 2 1 2 1 2
2 T516 A 1 LOH 50% LOH 1 2 1 2 1 2
2 1 2 50% LOH 1 2 1 2 1 2
B 1 50% LOH 50% LOH 1 2 1 2 1 2
2 50% LOH 50% LOH 1 2 1 2 1 2
C 1 1 2 1 2 1 2 1 2 1 2
2 1 2 1 2 1 2 1 2 1 2
3 T517 A 1 LOH 50% LOH 1 2 1 2 1 2
2 LOH 50% LOH 1 2 1 2 1 2
B 1 LOH 50% LOH 1 2 1 2 1 2
2 1 2 1 2 50% LOH 1 2 1 2
4 T518 A 1 1 2 50% LOH 50% LOH 1 2 1 2
2 LOH 1 2 50% LOH 1 2 50% LOH
B 1 LOH 50% LOH 1 2 1 2 1 2
2 1 2 1 2 1 2 1 2 1 2
C 1 1 2 1 2 1 2 1 2 1 2
2 1 2 1 2 1 2 1 2 1 2
5 T519 A 1 1 2 50% LOH 50% LOH 1 2 1 2
2 50% LOH 50% LOH 50% LOH 1 2 1 2
B 1 50% LOH 50% LOH 1 2 1 2 1 2
2 50% LOH 50% LOH 50% LOH 1 2 1 2
6 T521 A 1 LOH 1 2 1 2 1 2 1 2
2 LOH 1 2 1 2 1 2 1 2
B 1 LOH 1 2 1 2 1 2 1 2
2 LOH 1 2 1 2 1 2 1 2
7 T522 A 1 LOH 1 2 1 2 1 2 1 2
2 LOH 1 2 1 2 1 2 1 2
8 T523 A 1 LOH 1 2 1 2 1 2 1 2
2 LOH 1 2 1 2 LOH 1 2
9 T524 A 1 LOH 1 2 1 2 1 2 LOH
2 LOH 1 2 1 2 1 2 LOH
10 T525 A 1 LOH 1 2 1 2 1 2 1 2
2 LOH 1 2 1 2 1 2 1 2
B 1 LOH 1 2 1 2 1 2 LOH
2 LOH 1 2 1 2 1 2 LOH
  1. LOH denotes samples in which approximately 100% LOH of the second allele has occurred; 50% LOH denotes samples in which approximately 50% of the second allele was lost; 1 2 denotes samples in which the marker was clearly present in the heterozygous state, denoting the absence of LOH. The results represent the summed data for all markers analyzed at each genetic loci (NF1, TP53, RB1, CDKN2A and PTEN).