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Table 1 Analysis of molecular heterogeneity with respect to NF1 , TP53 , RB1 , CDKN2A , and PTEN in 10 MPNSTs

From: Molecular heterogeneity in malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1

Tumor

Tumor number

Tumor section

Tumor subsection

NF1

TP53

RB1

PTEN

CDKN2A

1

T196.22

A

1

LOH

LOH

LOH

LOH

LOH

 

2

LOH

LOH

LOH

LOH

LOH

 

3

LOH

LOH

50% LOH

LOH

LOH

 

4

1 2

1 2

1 2

1 2

1 2

 

5

LOH

LOH

50% LOH

LOH

LOH

 

6

LOH

LOH

LOH

LOH

LOH

 

7

LOH

LOH

LOH

LOH

LOH

 

8

LOH

LOH

50% LOH

50% LOH

LOH

 

9

1 2

LOH

1 2

LOH

LOH

 

10

1 2

LOH

1 2

LOH

LOH

B

1

LOH

50% LOH

50% LOH

50% LOH

1 2

 

2

LOH

50% LOH

50% LOH

50% LOH

1 2

 

3

LOH

50% LOH

50% LOH

50% LOH

1 2

 

4

LOH

50% LOH

50% LOH

50% LOH

1 2

 

5

50% LOH

50% LOH

50% LOH

50% LOH

1 2

 

6

LOH

50% LOH

50% LOH

50% LOH

1 2

 

7

LOH

50% LOH

50% LOH

50% LOH

1 2

 

8

LOH

50% LOH

50% LOH

50% LOH

1 2

 

9

LOH

50% LOH

50% LOH

50% LOH

1 2

 

10

LOH

50% LOH

50% LOH

50% LOH

1 2

C

1

LOH

LOH

50% LOH

LOH

1 2

2

LOH

LOH

50% LOH

LOH

1 2

3

LOH

LOH

50% LOH

LOH

1 2

4

LOH

LOH

50% LOH

LOH

1 2

5

1 2

LOH

1 2

50% LOH

50% LOH

6

LOH

LOH

50% LOH

LOH

50% LOH

7

LOH

LOH

50% LOH

LOH

50% LOH

8

LOH

LOH

50% LOH

LOH

50% LOH

9

LOH

LOH

50% LOH

LOH

50% LOH

10

LOH

LOH

50% LOH

LOH

50% LOH

D

1

LOH

LOH

50% LOH

LOH

50% LOH

2

LOH

LOH

50% LOH

50% LOH

1 2

3

LOH

LOH

50% LOH

LOH

LOH

4

LOH

LOH

50% LOH

LOH

LOH

5

LOH

LOH

50% LOH

LOH

LOH

6

LOH

LOH

50% LOH

LOH

LOH

7

LOH

LOH

50% LOH

LOH

LOH

8

LOH

LOH

50% LOH

LOH

LOH

9

LOH

LOH

50% LOH

LOH

LOH

10

LOH

LOH

50% LOH

LOH

LOH

E

1

LOH

1 2

1 2

1 2

1 2

2

LOH

1 2

1 2

50% LOH

1 2

3

50% LOH

1 2

1 2

1 2

1 2

4

LOH

1 2

1 2

50% LOH

1 2

5

1 2

1 2

1 2

0%

1 2

6

50% LOH

1 2

1 2

50% LOH

1 2

7

50% LOH

1 2

1 2

0%

1 2

8

LOH

1 2

1 2

1 2

1 2

9

LOH

1 2

1 2

1 2

1 2

10

LOH

1 2

1 2

1 2

1 2

2

T516

A

1

LOH

50% LOH

1 2

1 2

1 2

2

1 2

50% LOH

1 2

1 2

1 2

B

1

50% LOH

50% LOH

1 2

1 2

1 2

2

50% LOH

50% LOH

1 2

1 2

1 2

C

1

1 2

1 2

1 2

1 2

1 2

2

1 2

1 2

1 2

1 2

1 2

3

T517

A

1

LOH

50% LOH

1 2

1 2

1 2

2

LOH

50% LOH

1 2

1 2

1 2

B

1

LOH

50% LOH

1 2

1 2

1 2

2

1 2

1 2

50% LOH

1 2

1 2

4

T518

A

1

1 2

50% LOH

50% LOH

1 2

1 2

2

LOH

1 2

50% LOH

1 2

50% LOH

B

1

LOH

50% LOH

1 2

1 2

1 2

2

1 2

1 2

1 2

1 2

1 2

C

1

1 2

1 2

1 2

1 2

1 2

2

1 2

1 2

1 2

1 2

1 2

5

T519

A

1

1 2

50% LOH

50% LOH

1 2

1 2

2

50% LOH

50% LOH

50% LOH

1 2

1 2

B

1

50% LOH

50% LOH

1 2

1 2

1 2

2

50% LOH

50% LOH

50% LOH

1 2

1 2

6

T521

A

1

LOH

1 2

1 2

1 2

1 2

2

LOH

1 2

1 2

1 2

1 2

B

1

LOH

1 2

1 2

1 2

1 2

2

LOH

1 2

1 2

1 2

1 2

7

T522

A

1

LOH

1 2

1 2

1 2

1 2

2

LOH

1 2

1 2

1 2

1 2

8

T523

A

1

LOH

1 2

1 2

1 2

1 2

2

LOH

1 2

1 2

LOH

1 2

9

T524

A

1

LOH

1 2

1 2

1 2

LOH

2

LOH

1 2

1 2

1 2

LOH

10

T525

A

1

LOH

1 2

1 2

1 2

1 2

2

LOH

1 2

1 2

1 2

1 2

B

1

LOH

1 2

1 2

1 2

LOH

2

LOH

1 2

1 2

1 2

LOH

  1. LOH denotes samples in which approximately 100% LOH of the second allele has occurred; 50% LOH denotes samples in which approximately 50% of the second allele was lost; 1 2 denotes samples in which the marker was clearly present in the heterozygous state, denoting the absence of LOH. The results represent the summed data for all markers analyzed at each genetic loci (NF1, TP53, RB1, CDKN2A and PTEN).