Strong interaction between T allele of endothelial nitric oxide synthase with B1 allele of cholesteryl ester transfer protein TaqIB highly elevates the risk of coronary artery disease and type 2 diabetes mellitus

Table 3 The carrier odds ratio interaction between CETP B1 and NOS3 894 T alleles

CETP B1	NOS3 T	Total CAD patients n(%) ORs (95% CI) n = 207	CAD with T2DM n(%) ORs (95% CI) n = 102	CAD without T2DM n(%) ORs (95% CI) n = 105	T2DM patients n(%) ORs (95% CI) n = 101	Controls n(%) n = 92
−	−	3 (1.4)	2 (2)	1 (1)	2 (2)	8 (8.7)
−	+	3 (1.4)	3 (2.9)	0	2 (2)	12 (13)
−	+	0.67 (0.11–4.17, p = 0.67)	1 (0.14–7.4, p = 1)	0	0.67 (0.1–5.7, p = 0.71)	12 (13)
+	−	113 (54.6)	53 (52)	60 (57.1)	58 (57.4)	59 (64.2)
+	−	5.1 (1.3–20, p = 0.019)	3.6 (0.73–17.7, p = 0.11)	8.14 (1–67, p = 0.05)	3.9 (0.8–19.3, p = 0.09)	59 (64.2)
+	+	88 (42.6)	44 (43.1)	44 (41.9)	39 (38.6)	13 (14.1)
+	+	18.1 (4.2–76.8, p < 0.001)	13.5 (2.6–71.8, p = 0.002)	27.1 (3.1–237, p = 0.003)	12 (2.25–63.8, p = 0.004)	13 (14.1)

Interaction with respect to B2 or G alleles in CAD and T2DM patients compared with controls. Overall distribution of interaction between CETP B1 and NOS3 T alleles in total CAD compared to controls (χ² = 42.4, df = 3, p < 0.001) and between CAD with T2DM compared to controls (χ² = 25.7, df = 3, p < 0.001), as well as comparison between CAD without T2DM and controls (χ² = 33.6, df = 3, p < 0.001). Overall distribution of interaction between CETP B1 and NOS3 T alleles in T2DM patients compared to controls (χ² = 23.4, df = 3, p < 0.001).

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