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Table 3 The carrier odds ratio interaction between CETP B1 and NOS3 894 T alleles

From: Strong interaction between T allele of endothelial nitric oxide synthase with B1 allele of cholesteryl ester transfer protein TaqIB highly elevates the risk of coronary artery disease and type 2 diabetes mellitus

CETP B1 NOS3 T Total CAD patients n(%) ORs (95% CI) n = 207 CAD with T2DM n(%) ORs (95% CI) n = 102 CAD without T2DM n(%) ORs (95% CI) n = 105 T2DM patients n(%) ORs (95% CI) n = 101 Controls n(%) n = 92
3 (1.4) 2 (2) 1 (1) 2 (2) 8 (8.7)
+ 3 (1.4) 3 (2.9) 0 2 (2) 12 (13)
0.67 (0.11–4.17, p = 0.67) 1 (0.14–7.4, p = 1) 0.67 (0.1–5.7, p = 0.71)
+ 113 (54.6) 53 (52) 60 (57.1) 58 (57.4) 59 (64.2)
5.1 (1.3–20, p = 0.019) 3.6 (0.73–17.7, p = 0.11) 8.14 (1–67, p = 0.05) 3.9 (0.8–19.3, p = 0.09)
+ + 88 (42.6) 44 (43.1) 44 (41.9) 39 (38.6) 13 (14.1)
18.1 (4.2–76.8, p < 0.001) 13.5 (2.6–71.8, p = 0.002) 27.1 (3.1–237, p = 0.003) 12 (2.25–63.8, p = 0.004)
  1. Interaction with respect to B2 or G alleles in CAD and T2DM patients compared with controls. Overall distribution of interaction between CETP B1 and NOS3 T alleles in total CAD compared to controls (χ2 = 42.4, df = 3, p < 0.001) and between CAD with T2DM compared to controls (χ2 = 25.7, df = 3, p < 0.001), as well as comparison between CAD without T2DM and controls (χ2 = 33.6, df = 3, p < 0.001). Overall distribution of interaction between CETP B1 and NOS3 T alleles in T2DM patients compared to controls (χ2 = 23.4, df = 3, p < 0.001).