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Table 1 Human lens crystallin genes

From: The human crystallin gene families

Crystallin genes

Chr

α-crystallins

 

CRYAA/αA

21q22.3

CRYAB/αB

11q23.1

β-crystallins

 

CRYBA1/βA1, βA3

17q11.2

CRYBA2/βA2

2q35

CRYBA4/βA4

22q12.1

CRYBB1/βB1

22q12.1

CRYBB2/βB2

22q11.3

CRYBB2 P1

22q11.3

CRYBB3/βB3

22q11.23

γ-crystallins

 

CRYGA/γA

2q34

CRYGB/γB

2q34

CRYGC/γC

2q33.3

CRYGD/γD

2q33.3

CRYGEP/γE

2q33.3

CRYGFP/γF

2q34

CRYGS/γS

3q27.3

CRYGN/γN

7q36.1

CRYGGP

2p16.3

‘Enyzme-crystallin’

 

BHMT/ψ

5q14.1

  1. Gene/protein names and chromosome locations are shown. Genes/proteins in bold type are expressed at relatively high levels similar to orthologs in other mammals. Those in normal type seem to have reduced or no expression in human lens. Some are designated pseudogenes. The proposed crystallin designation for betaine-homocysteine methyltransferase (BHMT), ψ, does not imply pseudogene status.