Figure 1

Schematic representation of the domain compositions of the 21 proteins in the  PDI  gene family. All proteins contain a short NH₂-terminal signal sequence designated in black. Catalytically active TRX-like domains (a or a’) are represented in red with active sites noted; inactive TRX domains in blue (b) and purple (b’); green represents the Asp/Glu rich Ca²⁺-binding domains; linker regions (gray); transmembrane domains (yellow); COOH-terminal ER-retention sequences in white with a.a. composition denoted. Although ERP29 does contain an a-like domain, this is based on homology and not catalytic efficiency. Sequences and domain compositions were acquired and verified from the National Center for Biotechnology Information (NCBI) database. Figure was adapted and modified from [4].