Table 2 Amino acid similarity between human PDI proteins, as reported using EMBOSS Water Pairwise Alignment Algorithm ( http://www.ebi.ac.uk/Tools/psa/emboss_water/ )

AGR2

AGR3

65.0%

(81.4%)

CASQ1

18.8%

17.4%

(34.8%)

(40.2%)

CASQ2

15.3%

17.40%

68.4%

(37.4%)

(34.0%)

(86.1%)

DNAJC10

16.2%

19.0%

16.8%

18.2%

(37.2%)

(35.8%)

(33.3%)

(33.3%)

ERP27

28.2%

20.5%

17.2%

19.3%

18.6%

(41.0%)

(40.2%)

(34.4%)

(37.6%)

(35.8%)

ERP29

20.6%

23.3%

18.2%

20.4%

18.1%

15.7%

(40.2%)

(39.5%)

(31.1%)

(33.0%)

(30.9%)

(38.9%)

ERP44

22.2%

26.5%

19.2%

20.0%

20.4%

24.3%

25.3%

(39.4%)

(47.0%)

(42.9%)

(40.8%)

(30.6%)

(40.5%)

(42.0%)

P4HB

20.1%

21.7%

21.6%

22.9%

20.2%

32.5%

24.50%

23.5%

(34.3%)

(29.2%)

(39.3%)

(38.3%)

(36.0%)

(54.1%)

(39.9%)

(42.9%)

PDIA2

23.5%

20.8%

21.2%

20.6%

20.8%

28.6%

23.3.%

23.3%

47.3%

(35.5%)

(38.7%)

(31.8%)

(38.7%)

(32.1%)

(49.0%)

(37.2%)

(37.7%)

(64.5%)

PDIA3

21.7%

16.9%

21.5%

18.8%

21.4%

21.8%

22.3%

23.1%

33.6%

31.1%

(37.5%)

(37.9%)

(33.3%)

(31.3%)

(37.5%)

(38.9%)

(34.1%)

(40.6%)

(51.0%)

(49.5%)

PDIA4

19.80%

19.7%

18.8%

21.4%

17.5%

18.3%

29.6%

24.0%

36.8%

29.1%

41.9%

(31.6%)

(38.6%)

(38.2%)

(38.5%)

(30.8%)

(35.0)%

(48.1%)

(40.9%)

(55.1%)

(46.2%)

(60.2%)

PDIA5

24.2%

22.1%

21.3%

21.7%

21.4%

19.6%

19.7%

22.6%

24.3%

23.1%

22.9%

21.2%

(45.1%)

(44.1%)

(35.1%)

(36.9%)

(40.0%)

(33.5%)

(33.9%)

(40.6%)

(38.3%)

(35.0%)

(37.1%)

(31.5%)

PDIA6

27.6%

15.2%

24.0%

19.4%

32.7%

20.6%

17.0%

20.2%

23.5%

21.8%

24.2%

25.8%

28.1%

(35.2%)

(57.6%)

(40.6%)

(33.1%)

(48.0%)

(34.8)%

(32.2%)

(38.4%)

(31.4%)

(28.6%)

(33.4%)

(40.0%)

(43.1%)

PDILT

23.9%

16.2%

20.1%

21.1%

20.4%

29.7%

19.1%

21.9%

31.8%

32.1%

22.1%

26.0%

19.9%

23.5%

(45.7%)

(35.9%)

(43.4%)

(41.8%)

(36.1%)

(54.1%)

(38.5%)

(40.9%)

(52.4%)

(51.3%)

(37.1%)

(46.7%)

(35.3%)

(36.3%)

TMX1

18.6%

24.8%

23.7%

17.2%

21.1%

23.9%

15.5%

25.8%

29.9%

25.7%

30.0%

25.1%

35.0%

36.2%

27.0%

(36.1%)

(36.0%)

(37.8%)

(29.9%)

(38.2%)

(39.4%)

(32.3%)

(49.0%)

(46.9%)

(40.0%)

(50.0%)

(41.3%)

(56.4%)

(59.0%)

(39.3%)

TMX2

23.0%

18.6%

20.2%

28.6%

23.3%

22.0%

25.6%

23.10%

25.0%

28.3%

25.8%

25.7%

16.4%

24.7%

24.7%

24.6%

(36.1%)

(33.1%)

(39.9%)

(44.4%)

(44.8%)

(41.5%)

(43.6%)

(38.0%)

(40.9)

(44.6%)

(36.9%)

(43.7%)

(34.9%)

(38.9%)

(42.9%)

(43.1%)

TMX3

20.0%

19.7%

20.3%

21.8%

22.4%

18.1%

20.5%

21.4%

27.8%

21.6%

23.1%

27.1%

23.5%

45.3%

19.2%

34.2%

18.7%

(37.4%)

(36.5%)

(43.0%)

(43.6%)

(44.1%)

(33.3%)

(35.7%)

(34.7%)

(47.9%)

(40.3%)

(41.1%)

(42.7%)

(41.2%)

(64.2%)

(32.2%)

(50.5%)

(38.4%)

TMX4

23.5%

25.7%

27.0%

23.1%

23.7%

28.6%

19.5%

20.1%

21.8%

24.9%

24.3%

20.5%

27.2%

24.0%

25.0%

43.6%

24.4%

22.4%

(39.5%)

(36.6%)

(62.2%)

(47.3%)

(39.4%)

(42.9%)

(36.0%)

(37.0%)

(34.4%)

(37.0%)

(45.7%)

(32.1%)

(41.6%)

(37.1%)

(42.5%)

(65.0%)

(42.2%)

(34.2%)

TXNDC5

21.6%

20.9%

22.9%

20.7%

25.4%

22.0%

20.8%

33.3%

26.2%

26.9%

24.4%

23.5%

27.3%

33.0%

23.3%

24.6%

29.5%

51.4%

21.6%

(28.4%)

(39.5%)

(37.9%)

(34.0%)

(41.5%)

(37.9%)

(32.9%)

(50.0%)

(37.2%)

(37.5%)

(38.5%)

(34.1%)

(43.8%)

(53.0%)

(34.9%)

(33.8%)

(50.0%)

(71.6%)

(38.0%)

TXNDC12

34.2%

38.3%

20.0%

41.2%

18.5%

20.2%

27.5%

21.1%

26.2%

26.9%

24.1%

22.9%

22.7%

26.9%

23.1%

27.7%

21.6%

31.9%

18.7%

20.1%

(50.6%)

(53.9%)

(30.8%)

(70.6%)

(36.3%)

(30.2%)

(40.0%)

(32.2%)

(37.2%)

(37.5%)

(39.7%)

(41.2%)

(43.8%)

(37.0%)

(38.2%)

(39.8%)

(37.4%)

(48.9%)

(32.1%)

(31.5%)