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Figure 2 | Human Genomics

Figure 2

From: Extrapolating the effect of deleterious nsSNPs in the binding adaptability of flavopiridol with CDK7 protein: a molecular dynamics approach

Figure 2

Change in the surrounding amino acid residues in CDK7 protein by the substitution of deleterious amino acid. (A) The native type isoleucine residue (green) at position 63 and the surrounding residues. Substitution of I63 residue with arginine (red) brings more surrounding residues in contact at position 63. (B) The native type histidine residue (green) at position 135 and its surrounding amino acid residues. Substitution of arginine (red) at position 135 brings more amino acids in the surrounding region. (C) Native type residue threonine (green) at position 285 and its surrounding amino acid residues. Substitution of methionine (red) at position 285 brings two more residues val192 and met196 within the 4 A0 surrounding.

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Human Genomics

ISSN: 1479-7364