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Figure 3 | Human Genomics

Figure 3

From: Extrapolating the effect of deleterious nsSNPs in the binding adaptability of flavopiridol with CDK7 protein: a molecular dynamics approach

Figure 3

Interaction of flavopiridol with native and mutant models of CDK7 protein. (A) Flavopiridol binds deeply with native CDK7 protein and makes contact with 12 amino acid residues. (B) Substitution of I63 with arginine reduced the binding affinity of flavopiridol in mutant model I63R. (C) Substitution of H135 with arginine, results in weak interaction of ligand flavopiridol with H135R model. (D) Flavopiridol binds shallowly on the surface of mutant model T285M and the number of amino acid contact become reduced.

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Human Genomics

ISSN: 1479-7364