Comparative study and meta-analysis of meta-analysis studies for the correlation of genomic markers with early cancer detection

Table 1 Summary of genes and SNPs identified by meta-analysis to be positively correlated with various cancers

Gene	Cancer type	SNPs		References	Supporting references
		rs number	Other name
ERCC2	BC	rs13181	p.K715Q	[12, 13]	[14–17]
ERCC2	BC	rs1799793	p.D312N	[12, 18]	[14–16]
ERCC2	LC	rs13181	p.K751Q	[19, 20]	[17, 21, 22]
ERCC2	LC	rs1799793	p.D312N	[23]	[17, 21, 22]
CCND1	BC	rs603965	c.870G>A	[24]	[25–31]
CYP2E1	CRC	rs3813867	NA	[32]	[32–41]^a
CYP2E1	HNC	rs3813867	NA	[42, 43]	[44]
CYP2E1	HNC	rs6413432	NA	[42]	[44]
GSTP1	CRC	rs1695	p.I105V	[45]	[39, 46–55]
IL6	BC	rs1800795	c.-174G>C	[56, 57]
MTHFR	GC	rs1801131	c.1298A>C	[58]	[59, 60]^b
MTHFR	BC	rs1801131	c.677C>T, c.1298A>C	[61, 62]	[63, 64]
SOD2	BC	rs4880	p.V16A, p.A9V	[62, 65, 66]
TGFB1	BC	rs1800469	NA	[67–69]
TGFB1	BC	rs1800470	NA	[67, 70–73]
TGFB1	BC	rs1982073	NA	[74]	[64, 75–77]
TP53	BC	rs1042522	p.R72P	[78, 79]	[80–94]
TP53	UBC	rs1042522	p.R72P	[95]	[96–100]
TP53	CRC	rs1042522	p.R72P	[78, 101–103]	[104–108]
TP53	CRC	rs17878362	NA	[78]	[104–108]
TP53	EC	rs1042522	p.R72P	[109, 110]	[111]
TP53	LC	rs1042522	p.R72P	[78]	[112–117]
TP53	LC	rs17878362	NA	[78]	[112–117]
VEGFA	BC	rs3025039, rs699947	c.936C>T, c.-2578C>A	[20, 45, 118, 119]	[120]

These findings are supported by the published literature. ^aFor a different SNP (rs1329149); ^bfor c.677C>T and c.1298A>C. NA not available.

ISSN: 1479-7364