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Table 4 Summary of gene-gene interactions and the corresponding SNPs in these genes

From: Comparative study and meta-analysis of meta-analysis studies for the correlation of genomic markers with early cancer detection

Gene 1 Gene 2 Cancer type SNP's gene 1 SNP's gene 2 References (gene 1) References (gene 2) Supporting references
    rs number Other name rs number Other name    
IL6 TGFB1 BC rs1800795 c.-174G>C rs1800469, rs1800470 c.-509C>T, p.T29C [56] [6770, 7274] [155157]
IL6 TGFB1 CRC rs1800795 c.-174G>C rs1800470 p.T29C [57] [71] [158]
IL6 TGFB1 GC rs1800795 c.-174G>C rs1800470 p.T29C [57] [71]  
IL6 TGFB1 LC rs1800795 c.-174G>C rs1800470 p.T29C [57] [71]  
IL6 TGFB1 PC rs1800795 c.-174G>C rs1800470 p.T29C [57] [71] [159]
MMP2 EGF LC rs2438650 c.-1306C>T rs4444903 c.61A>G [160] [161] [162]
MMP2 EGF BC rs2438650 c.-1306C>T rs4444903 c.61A>G [160] [161] [163165]
MMP2 EGF GC rs2438650 c.-1306C>T rs4444903 c.61A>G [160] [161]  
VEGFA IL1B BC rs3025039 c.936C>T rs114327 NA [166169] [170] [171]
VEGFA IL1B BC rs699947 c.-2578C>A rs1143634 NA [172] [170] [171]
VEGFA IL1B BC NA NA rs16944 NA NA [170] [171]
VEGFA IL1B GC rs3025039 c.936C>T rs3087258 NA [45] [173]  
VEGFA IL1B GC rs699947 c.-2578C>A NA IL1B-31-ami [95] [173]  
MMP9 IL8 BC rs3918242 c.-1562C>T rs4073 c.-251A>T [160] [174] [171]
MMP9 IL8 CRC rs3918242 c.-1562C>T rs4073 c.-251A>T [160] [174]  
MMP9 IL8 GC rs3918242 c.-1562C>T rs4073 c.-251A>T [160] [175]  
MMP9 IL8 LC rs3918242 c.-1562C>T rs4073 c.-251A>T [160] [174]  
MMP1 MMP3 BC rs1799750 c.-1607 1G>2G rs3025058 c.-1171 5A>6A [176] [176]  
MMP1 MMP3 CRC rs1799750 c.-1607 1G>2G rs3025058 c.-1171 5A>6A [176] [176]  
MMP1 MMP3 HNC rs1799750 c.-1607 1G>2G rs3025058 c.-1171 5A>6A [176] [176]  
MMP1 MMP3 LC rs1799750 c.-1607 1G>2G rs3025058 c.-1171 5A>6A [176] [176] [177, 178]
MMP1 MMP3 OVCa rs1799750 c.-1607 1G>2G rs3025058 c.-1171 5A>6A [176] [176]  
GSTP1 GSTM1 CRC rs1695 p.I105V rs1065411 GSTM1 present/null [45] [179]  
GSTP1 GSTM1 BC rs1695 p.I105V rs1065412 GSTM1 present/null [180] [181] [182, 183]
GSTP1 GSTM1 OVCa rs1695 p.I105V rs1065413 GSTM1 present/null [184] [184]  
GSTP1 GSTM1 UBC rs1695 p.I105V rs1065414 GSTM1 present/null [185] [186]  
  1. These were identified in our meta-analysis. Their correlation with various cancer types is also shown. NA not available.