Skip to main content

Table 4 Summary of gene-gene interactions and the corresponding SNPs in these genes

From: Comparative study and meta-analysis of meta-analysis studies for the correlation of genomic markers with early cancer detection

Gene 1

Gene 2

Cancer type

SNP's gene 1

SNP's gene 2

References (gene 1)

References (gene 2)

Supporting references

   

rs number

Other name

rs number

Other name

   

IL6

TGFB1

BC

rs1800795

c.-174G>C

rs1800469, rs1800470

c.-509C>T, p.T29C

[56]

[67–70, 72–74]

[155–157]

IL6

TGFB1

CRC

rs1800795

c.-174G>C

rs1800470

p.T29C

[57]

[71]

[158]

IL6

TGFB1

GC

rs1800795

c.-174G>C

rs1800470

p.T29C

[57]

[71]

 

IL6

TGFB1

LC

rs1800795

c.-174G>C

rs1800470

p.T29C

[57]

[71]

 

IL6

TGFB1

PC

rs1800795

c.-174G>C

rs1800470

p.T29C

[57]

[71]

[159]

MMP2

EGF

LC

rs2438650

c.-1306C>T

rs4444903

c.61A>G

[160]

[161]

[162]

MMP2

EGF

BC

rs2438650

c.-1306C>T

rs4444903

c.61A>G

[160]

[161]

[163–165]

MMP2

EGF

GC

rs2438650

c.-1306C>T

rs4444903

c.61A>G

[160]

[161]

 

VEGFA

IL1B

BC

rs3025039

c.936C>T

rs114327

NA

[166–169]

[170]

[171]

VEGFA

IL1B

BC

rs699947

c.-2578C>A

rs1143634

NA

[172]

[170]

[171]

VEGFA

IL1B

BC

NA

NA

rs16944

NA

NA

[170]

[171]

VEGFA

IL1B

GC

rs3025039

c.936C>T

rs3087258

NA

[45]

[173]

 

VEGFA

IL1B

GC

rs699947

c.-2578C>A

NA

IL1B-31-ami

[95]

[173]

 

MMP9

IL8

BC

rs3918242

c.-1562C>T

rs4073

c.-251A>T

[160]

[174]

[171]

MMP9

IL8

CRC

rs3918242

c.-1562C>T

rs4073

c.-251A>T

[160]

[174]

 

MMP9

IL8

GC

rs3918242

c.-1562C>T

rs4073

c.-251A>T

[160]

[175]

 

MMP9

IL8

LC

rs3918242

c.-1562C>T

rs4073

c.-251A>T

[160]

[174]

 

MMP1

MMP3

BC

rs1799750

c.-1607 1G>2G

rs3025058

c.-1171 5A>6A

[176]

[176]

 

MMP1

MMP3

CRC

rs1799750

c.-1607 1G>2G

rs3025058

c.-1171 5A>6A

[176]

[176]

 

MMP1

MMP3

HNC

rs1799750

c.-1607 1G>2G

rs3025058

c.-1171 5A>6A

[176]

[176]

 

MMP1

MMP3

LC

rs1799750

c.-1607 1G>2G

rs3025058

c.-1171 5A>6A

[176]

[176]

[177, 178]

MMP1

MMP3

OVCa

rs1799750

c.-1607 1G>2G

rs3025058

c.-1171 5A>6A

[176]

[176]

 

GSTP1

GSTM1

CRC

rs1695

p.I105V

rs1065411

GSTM1 present/null

[45]

[179]

 

GSTP1

GSTM1

BC

rs1695

p.I105V

rs1065412

GSTM1 present/null

[180]

[181]

[182, 183]

GSTP1

GSTM1

OVCa

rs1695

p.I105V

rs1065413

GSTM1 present/null

[184]

[184]

 

GSTP1

GSTM1

UBC

rs1695

p.I105V

rs1065414

GSTM1 present/null

[185]

[186]

 
  1. These were identified in our meta-analysis. Their correlation with various cancer types is also shown. NA not available.
Back to article page

Human Genomics

ISSN: 1479-7364