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Table 6 Over-represented pathways and GOs

From: Rank-based genome-wide analysis reveals the association of Ryanodine receptor-2 gene variants with childhood asthma among human populations

 

pvalues

 

EA

AA

HA

GO

   

  Cellular response to stress

0.0006

1

1

  Vitamin binding

0.0056

0.3392

1

  JAK STAT cascade

0.0062

1

0.4304

  Vitamin transport

0.0072

0.3210

0.2886

  ER nuclear signaling pathway

0.0078

1

1

  Regulation of gene-specific transcription

0.0078

1

1

  Positive regulation of cell proliferation

0.4326

0.0006

0.4412

  Lysosomal transport

1

0.0016

1

  Carbohydrate binding

0.6714

0.0038

0.8342

  RNA catabolic process

0.3710

0.0050

0.2818

  Vacuolar transport

1

0.0052

1

  Negative regulation of catalytic activity

0.7328

0.1720

0.0004

  Protein kinase binding

1

0.7450

0.0016

  Kinase binding

0.8654

0.5054

0.0040

  Regulation of translation

0.8478

1

0.0050

  Anion transmembrane transporter activity

1

0.7148

0.0080

  Negative regulation of hydrolase activity

1

1

0.0100

Pathway

   

  BioCarta G2 pathway

0.0008

1

1

  Reactome E2F transcriptional targets at G1 S

0.0034

1

1

  Reactome E2F mediated regulation of DNA replication

0.0036

1

1

  KEGG alanine aspartate and glutamate metabolism

0.5218

0.0032

0.4338

  BioCarta longevity pathway

0.4426

0.0088

1

  Reactome amine ligand binding receptors

0.3642

0.1202

0.0006

  Reactome G alpha S signaling events

0.3682

0.8264

0.0060

  1. With p value <0.01 in at least one of the three populations when the top 1,000 SNPs are declared as noteworthy. EA, European-American; AA, African-American; HA, Hispanic-American populations; KEGG, Kyoto encyclopedia of genes and genomes.