Role of conserved cis-regulatory elements in the post-transcriptional regulation of the human MECP2 gene involved in autism

Table 1 A total of four MECP2 mammalian orthologs were chosen for the current studies

MECP2 ortholog	Nucleotide sequence (mRNA) identity to human	Protein sequence identity/similarity to human	Protein length (amino acids)
Homo sapiens [RefSeq:NM_004992.3]	100%	100%	486
Canis lupus familiaris [RefSeq:XM_848395.1]	92.50%	96%/97%	486
Mus musculus [RefSeq:NM_001081979.1]	85.00%	95%/96%	501
Rattus norvegicus [RefSeq:NM_022673.1]	78.20%	94%/95%	492

RNAs were aligned pairwise by semi-global method which does not penalize end-gaps. Therefore, the percentage similarity calculations do not include differences in the lengths of untranslated regions. Values in parentheses represent NCBI accession numbers of the corresponding mRNAs.

ISSN: 1479-7364