Figure 1
From: K-Map: connecting kinases with therapeutics for drug repurposing and development
Query and results of the K-Map. Left, query features. K-Map could bequeried by: (A) direct input or directly uploading a list of kinases inthe K-Map tab, (B) by selecting kinases from the kinase family, or(C) querying by Gene Ontology Biological Processes. All druginformation is available in the Drug Info tab (D) and could bedownloaded in the Download tab. Right, connectivity results. Query kinases wereconnected to the inhibitors and sorted by normalized connectivity scores.Link-out features include PubMed, PubChem, ChEMBL, and ChemSpider for drugsources and information. K-Map also provides links to pathway, biomarker, andclinical trial information for each drug via KEGG, GDSC, and ClinicalTrials.govdatabases, respectively.