Clade name | Clade | Serpin gene name | Known aliases | Biological function | References |
---|---|---|---|---|---|
Alpha 1 proteinase inhibitor antitrypsin | A | SERPINA1 | Alpha 1PI | Inflammation, complement activation, apoptosis | 17 |
SERPINA2 | Â | Â | Â | ||
SERPINA3 | Alpha1 ACT | Apoptosis, Alzheimer’s disease, prohormone conversion, inflammation and complement activation | 3,16 | ||
SERPINA4 | PI4, KST, KAL | Kidney function, inflammation, and complement activation | 18 | ||
SERPINA5 | PCI | Coagulation, inflammation, complement activation, sperm development | Â | ||
SERPINA6 | CBG | Hormone transport | 16 | ||
SERPINA7 | TBG | Hormone transport | Â | ||
AGT | SERPINA8 | Blood pressure regulation, renal development | 19 | ||
SERPINA9 | Centurin | B cell development | 3 | ||
SERPINA10 | PZI | Inhibition of activated factors Z and XI | 3 | ||
SERPINA11 | Â | Â | Â | ||
SERPINA12 | Vaspin | Inhibits kallikrein; unknown role in insulin sensitivity | 20,21 | ||
SERPINA13P | Â | Â | Â | ||
SERPINB1 | PI2, LEI, MNEI, EI | Inflammation, complement activation | 3 | ||
SERPINB2 | PAI2, placental PAI, monocyte ARG serpin, PLANH2 | Fibrinolysis, elastase inhibitor | 3 | ||
ov Serpins | B | SERPINB3 | SCCA1, SCC | Inhibition of cathepsins, tumor promotion | 32 |
SERPINB4 | SCCA2, PI11 | Inhibition of cathepsins and chymase | 33 | ||
SERPINB5 | Maspin, PI5 | Tumor cell invasion, angiogenesis | 3 | ||
SERPINB6 | DFNB91, PI6, CAP | Cathepsin inhibitor | 34 | ||
SERPINB7 | Megsin | Renal development, mesangial cell proliferation | 35 | ||
SERPINB8 | PI8, CAP2 | Uncharacterized | 3 | ||
SERPINB8P1 | Â | Â | Â | ||
SERPINB9 | PI9, CAP3 | Â | Â | ||
SERPINB10 | PI10, BOMAPIN | Hematapoetic and myeloid development | 35 | ||
SERPINB11 | EPIPIN | Uncharacterized | 36 | ||
SERPINB12 | YUKOPIN | Trypsin inhibition | 37 | ||
SERPINB13 | PI13, headpin, HUR7, hurpin | Â | Â | ||
Antithrombin | C | SERPINC1 | AT3, ATIII, antithrombin3 | Coagulation, angiogenesis | 38 |
Heparin cofactor | D | SERPIND1 | HCFII, HCF2, heparin cofactor II, HLS2 | Coagulation | 40 |
Nexin/plasminogen activator inhibitor 1 | E | SERPINE1 | PAI, PLANH1 | Angiogenesis, fibrinolysis | 3 |
SERPINE2 | PI7, GDN, ‘glial-derived nexin 1,’ nexin, PN1, PNI | Neurotrophic factor | 41 | ||
SERPINE3 | Â | Â | Â | ||
Alpha 2 antiplasmin pigment epithelium derived factor | F | SERPINF1 | PEDF | Neurotrophic factor, angiogenesis | 16 |
SERPINF2 | Alpha 2AP, PLI, A2AP, AAP, ‘alpha-2-antiplasmin,’ ALPHA‒2‒PI, ‘alpha‒2‒plasmin inhibitor,’ API | Fibrinolysis | 3 | ||
C1 inhibitor | G | SERPING1 | C1NH,C1–INH, C1IN, HAE1, HAE2, ‘plasma protease C1 inhibitor’ | Microbial infection | 42 |
Heat shock protein | H | SERPINH1 | CBP1, CBP2, collagen, HSP47 | Chaperone | 43 |
Neuroserpin | I | SERPINI1 | Neuroserpin, PI12 | Neurotrophic factor | 46 |
 |  | SERPINI2 | Pancpin, PI14, TSA2004, MEPI | Tumor cell invasion | 47 |