Skip to main content

Table 1 SERPIN aliases and function

From: Update of the human and mouse SERPINgene superfamily

Clade name

Clade

Serpin gene name

Known aliases

Biological function

References

Alpha 1 proteinase inhibitor antitrypsin

A

SERPINA1

Alpha 1PI

Inflammation, complement activation, apoptosis

17

SERPINA2

   

SERPINA3

Alpha1 ACT

Apoptosis, Alzheimer’s disease, prohormone conversion, inflammation and complement activation

3,16

SERPINA4

PI4, KST, KAL

Kidney function, inflammation, and complement activation

18

SERPINA5

PCI

Coagulation, inflammation, complement activation, sperm development

 

SERPINA6

CBG

Hormone transport

16

SERPINA7

TBG

Hormone transport

 

AGT

SERPINA8

Blood pressure regulation, renal development

19

SERPINA9

Centurin

B cell development

3

SERPINA10

PZI

Inhibition of activated factors Z and XI

3

SERPINA11

   

SERPINA12

Vaspin

Inhibits kallikrein; unknown role in insulin sensitivity

20,21

SERPINA13P

   

SERPINB1

PI2, LEI, MNEI, EI

Inflammation, complement activation

3

SERPINB2

PAI2, placental PAI, monocyte ARG serpin, PLANH2

Fibrinolysis, elastase inhibitor

3

ov Serpins

B

SERPINB3

SCCA1, SCC

Inhibition of cathepsins, tumor promotion

32

SERPINB4

SCCA2, PI11

Inhibition of cathepsins and chymase

33

SERPINB5

Maspin, PI5

Tumor cell invasion, angiogenesis

3

SERPINB6

DFNB91, PI6, CAP

Cathepsin inhibitor

34

SERPINB7

Megsin

Renal development, mesangial cell proliferation

35

SERPINB8

PI8, CAP2

Uncharacterized

3

SERPINB8P1

   

SERPINB9

PI9, CAP3

  

SERPINB10

PI10, BOMAPIN

Hematapoetic and myeloid development

35

SERPINB11

EPIPIN

Uncharacterized

36

SERPINB12

YUKOPIN

Trypsin inhibition

37

SERPINB13

PI13, headpin, HUR7, hurpin

  

Antithrombin

C

SERPINC1

AT3, ATIII, antithrombin3

Coagulation, angiogenesis

38

Heparin cofactor

D

SERPIND1

HCFII, HCF2, heparin cofactor II, HLS2

Coagulation

40

Nexin/plasminogen activator inhibitor 1

E

SERPINE1

PAI, PLANH1

Angiogenesis, fibrinolysis

3

SERPINE2

PI7, GDN, ‘glial-derived nexin 1,’ nexin, PN1, PNI

Neurotrophic factor

41

SERPINE3

   

Alpha 2 antiplasmin pigment epithelium derived factor

F

SERPINF1

PEDF

Neurotrophic factor, angiogenesis

16

SERPINF2

Alpha 2AP, PLI, A2AP, AAP, ‘alpha-2-antiplasmin,’ ALPHA‒2‒PI, ‘alpha‒2‒plasmin inhibitor,’ API

Fibrinolysis

3

C1 inhibitor

G

SERPING1

C1NH,C1–INH, C1IN, HAE1, HAE2, ‘plasma protease C1 inhibitor’

Microbial infection

42

Heat shock protein

H

SERPINH1

CBP1, CBP2, collagen, HSP47

Chaperone

43

Neuroserpin

I

SERPINI1

Neuroserpin, PI12

Neurotrophic factor

46

  

SERPINI2

Pancpin, PI14, TSA2004, MEPI

Tumor cell invasion

47

  1. SERPINS are divided into clades and gene name with known aliases and biological function are provided. Alternative name information was determined using HGNC (http://www.genenames.org) and/or MGI (http://www.informatics.jax.org).