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Figure 4 | Human Genomics

Figure 4

From: Viral expression associated with gastrointestinal adenocarcinomas in TCGA high-throughput sequencing data

Figure 4

Circos plot for HPV-18 RNA-seq. From outside to the inside of the circle: (1) HPV-18 genomic positions; (2) number of sequencing reads mapped to the viral genome in 64 colon and rectum adenocarcinomas combined. Range from 1 to 10 shown on light yellow background as a black line, and from 11 to 61 on light green background as a green line; (3) viral genes mapped to genomic positions. While expression of genes E6, E7, and E1 is obvious, genes L2, E5, E4, and part of E2 were not detected. This pattern is expected when HPV-18 integrates in the host genome and part of the viral genome becomes deleted.

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