A study of the role of GATA4 polymorphism in cardiovascular metabolic disorders

Table 1 Association of GATA4 gene variants with coronary artery disease, myocardial infarction congenital heart disease

Block	Haplotype	Pooled	Cases	Control	χ2	pvalue
Hypercholesterolaemia
1–9	AACCCATGT	0.063	0.071	0.060	3.86	0.050
5–10	CATGTC	0.088	0.096	0.082	4.25	0.039
High low-density lipoprotein
1–10	AACCCATGTC	0.062	0.079	0.062	4.83	0.028
	GACCCATGCC	0.015	0.024	0.015	4.94	0.026
1–9	AACCCATGT	0.063	0.078	0.062	4.31	0.038
Hypertriglyceridaemia
2–7	ACACAT	0.083	0.072	0.088	4.79	0.029
2–6	ACCTA	0.013	0.018	0.011	4.65	0.031
3–6	CCTA	0.016	0.021	0.014	4.34	0.037
1–5	AACCT	0.01	0.015	0.009	4.49	0.034
Hypertension
1–8	GACCCACG	0.02	0.018	0.026	4.26	0.039
1–6	GACCCA	0.103	0.098	0.119	6.78	0.009
Type 2 diabetes mellitus
1–9	GACACACCC	0.18	0.192	0.175	4.05	0.044
Obesity
1–10	GACCCGCGCC	0.025	0.032	0.022	7.59	0.006**
	GACCCGCGC	0.026	0.033	0.022	7.42	0.006**
2–10	ACCCGCGCC	0.026	0.031	0.022	6.55	0.011
3–10	CCCGCGCC	0.026	0.031	0.022	6.55	0.011
1–8	GACCCGCG	0.028	0.033	0.024	5.27	0.022
1–7	GACCCGC	0.028	0.033	0.024	6.14	0.013
4–10	CCGCGCC	0.026	0.031	0.022	5.97	0.015
3–9	CCCGCGC	0.027	0.033	0.023	6.88	0.009
2–8	ACCCGCG	0.028	0.033	0.025	4.53	0.033
3–8	CCCGCG	0.027	0.032	0.024	5.23	0.022
3–7	CCCGC	0.029	0.034	0.025	5.33	0.021
5–9	CGCGC	0.030	0.035	0.026	5.08	0.024

The table shows selected haplotypes associated with the disease. The most frequent 10-mer haplotype (0.14) was employed as the baseline to determine the relative effects of the other haplotypes. The studied SNPs are rs2740434 (also denoted as 1), rs17153743 (2), rs13264774 (3), rs56298569 (4), rs804280 (5), rs3729855 (6), rs3729856 (7), rs1062219 (8), rs11785481 (9) and rs3203358 (10) arranged sequentially by their chromosomal positions, whereby blocks represent the range of variants constituting the respective haplotypes. *p < 0.01; **p < 0.005 by χ² test.

ISSN: 1479-7364