A study of the role of GATA4 polymorphism in cardiovascular metabolic disorders

Table 2 Association of GATA4 gene variants with metabolic disease risk traits

Block	Haplotype	Pooled	Cases	Control	χ2	pvalue
Coronary artery disease
1–8	GACCCGTG	0.108	0.114	0.101	3.84	0.050
3–10	CCCGTGCC	0.110	0.116	0.102	4.17	0.041
2–9	ACCCGTGC	0.112	0.119	0.105	3.87	0.049
	ACCCATGC	0.026	0.029	0.022	4.08	0.044
1–7	GACCCGT	0.109	0.116	0.102	3.93	0.048
	CCCATGC	0.026	0.029	0.022	3.81	0.050
2–8	ACCCGTG	0.113	0.120	0.105	4.51	0.034
4–10	CCGTGCC	0.111	0.118	0.104	3.91	0.048
4–9	ACATCC	0.069	0.064	0.075	4.60	0.032
3–8	CCCGTG	0.114	0.121	0.106	4.63	0.031
2–7	ACCCGT	0.119	0.126	0.111	4.66	0.031
3–7	CCCGT	0.119	0.126	0.110	4.96	0.026
1–5	GACCC	0.239	0.250	0.228	5.48	0.019
4–8	CCGTG	0.116	0.122	0.108	4.21	0.040
1–4	GACC	0.244	0.254	0.232	5.69	0.017
4–7	CCGT	0.121	0.129	0.113	4.73	0.030
2–5	ACCC	0.403	0.416	0.387	7.17	0.007*
Myocardial infarction
1–10	AACACATCCC	0.04	0.038	0.049	6.01	0.014
1–9	AACACATCC	0.041	0.038	0.050	6.33	0.012
1–8	AACACATC	0.042	0.038	0.050	6.54	0.011**
2–9	ACCCACGC	0.029	0.033	0.023	6.58	0.010**
3–9	CCCACGC	0.029	0.032	0.023	5.97	0.015
2–8	ACCCACG	0.033	0.037	0.026	6.76	0.009**
6–10	GTCCC	0.014	0.016	0.011	3.84	0.050
4–8	CCACG	0.034	0.038	0.028	5.60	0.018
4–8	ATAC	0.013	0.010	0.018	7.98	0.005**
2–5	ACCC	0.403	0.410	0.387	4.07	0.044

The table shows selected haplotypes associated with disease. The most frequent 10-mer haplotype (0.14) was employed as the baseline to determine the relative effects of the other haplotypes. The studied SNPs are rs2740434 (also denoted as 1), rs17153743 (2), rs13264774 (3), rs56298569 (4), rs804280 (5), rs3729855 (6), rs3729856 (7), rs1062219 (8), rs11785481 (9) and rs3203358 (10) arranged sequentially by their chromosomal positions, and blocks represent the range of variants constituting the respective haplotypes. *p < 0.01; **p < 0.005 by χ² test.

ISSN: 1479-7364