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Table 3 Association of GATA4 haplotypes with coronary artery disease/myocardial infarction

From: A study of the role of GATA4 polymorphism in cardiovascular metabolic disorders

Variant

Genotype/allele

Controls

Cases

Univariate analysis

Multivariate analysis

    

pvalue

Exp (B)(95% CI)

Correctedpvalue

Exp (B″)(95% CI)

Hypercholesterolaemia

 rs804291CT

TT

0.016

0.027

0.023*

1.66(1.07–2.57)

0.037*

1.61(1.03–2.52)

 rs11785481CT

CT + TT

0.196

0.220

0.065

1.16(0.99–1.34)

0.087

1.15(0.98–1.35)

 rs3203358CG

CG + GG

0.358

0.323

0.020*

0.85(0.75–0.98)

0.026*

0.86(0.75–0.98)

Hypertriglyceridaemia

 rs3729855CT

T

0.030

0.041

0.023

1.35(1.01–1.78)

0.004**

1.49(1.14–1.94)

CT + TT

0.053

0.070

0.005**

1.34(1.09–1.64)

0.010*

1.47(1.10–1.96)

 rs1062219CT

TT

0.220

0.182

0.011*

0.79(0.67–0.98)

0.016*

0.80(0.67–0.99)

Elevated low-density lipoprotein-cholesterol

 rs804291CT

TT

0.018

0.033

0.016*

1.90(1.13–3.21)

0.020*

1.87(1.10–3.15)

 rs11785481CT

CT + TT

0.201

0.229

0.032*

1.18(1.01–1.37)

0.136

1.18(0.95–1.45)

Low high-density lipoprotein-cholesterol

 rs2740434CT

CT + TT

0.084

0.069

0.013*

0.81(0.69–0.96)

0.744

0.93(0.62–1.41)

Hypertension

 rs3729855CT

T

0.027

0.035

0.089

1.30(0.95–1.77)

0.013*

1.52(1.09–2.11)

 rs17153743AG

AG + GG

0.017

0.031

0.022*

1.87(1.10–3.18)

0.005*

2.30(1.30–4.26)

 rs13264774CT

T

0.041

0.024

0.008*

0.59(0.40–0.87)

0.085

0.68(0.44–1.05)

Type 2 diabetes mellitus

 rs3729855CT

T

0.040

0.028

0.003*

0.70(0.55–0.89)

0.003*

0.68(0.53–0.88)

 rs13264774CT

CT + TT

0.035

0.023

0.025*

0.66(0.045–0.95)

0.199

0.76(0.51–1.16)

Obesity

 rs17153743AG

GG

0.138

0.070

0.031

0.73(0.55–0.98)

0.357

0.94(0.82–1.07)

 rs11785481CT

TT

0.029

0.022

0.033*

0.73(0.55–0.98)

0.903

0.84(0.73–0.95)

 rs2740434GA

GA + AA

0.086

0.065

0.013*

0.73(0.50–0.94)

0.011*

0.72(0.56–0.93)

  1. The table summarizes the univariate and multivariate analyses for the relationships of the gene variants with various cardiovascular disease traits. Bonferroni tests have been performed to adjust for age and sex and adjustment made for the confounders in the multivariate tests. *p < 0.05; **p < 0.005.
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Human Genomics

ISSN: 1479-7364