A study of the role of GATA4 polymorphism in cardiovascular metabolic disorders

Table 5 Patient Demographics and clinical data

Variant	Genotype/allele	Controls	Cases	Univariate analysis		Multivariate analysis
				pvalue	Exp (B)(95% CI)	Correctedpvalue	Exp (B″)(95% CI)
Coronary artery disease
rs3729855CT	T	0.037	0.030	0.047*	0.78(0.62–1.00)	0.315	0.87(0.67–1.14)
rs3203358CG	G	0.206	0.191	0.074	0.90(0.82–1.00)	0.042*	0.88(0.78–0.99)
rs1062219CT	CT + TT	0.663	0.694	0.034*	1.15 (1.01–1.31)	0.091	1.13(0.98–1.31)
rs17153743AG	AG + GG	0.033	0.022	0.036*	0.67(0.47–0.98)	0.032*	0.67(0.43–0.96)
rs804280AC	C	0.420	0.446	0.018*	1.11(1.02–1.21)	0.009*	1.14(1.03–1.27)
rs804280AC	AC + CC	0.647	0.688	0.005**	1.20(1.06–1.36)	0.012*	1.20(1.03–1.39)
Myocardial infarction
rs3729855CT	T	0.040	0.030	0.020*	0.75(0.59–0.96)	0.323	0.86(0.86–1.56)
rs3729856AG	GG	0.031	0.041	0.024*	1.34(1.04–1.72)	0.146	1.42(0.88–2.33)
rs13264774CT	CT + TT	0.269	0.247	0.029*	0.89(0.80–0.99)	0.103	0.84(0.69–1.04)
rs804280AC	AC + CC	0.645	0.681	0.020*	1.17(1.07–1.29)	0.511	1.07(0.88–1.28)
Congenital heart disease
rs3729856AG	G	0.145	0.215	0.012*	1.61(1.11–2.30)	0.081	1.51(0.95–2.40)
rs3729856AG	AG + GG	0.280	0.362	0.018*	1.45(1.07–1.99)	0.108	1.57(0.90–2.73)
rs12825CG	CG + GG	0.777	0.854	0.010*	1.68(1.13–2.50)	0.108	1.71(0.89–3.29)
rs11785481CT	T	0.115	0.154	0.037*	1.41(1.02–1.94)	0.030*	1.78(1.06–3.00)
rs11785481CT	CT + TT	0.190	0.275	0.053*	1.61(1.15–2.27)	0.183	1.50(0.83–2.75)
rs2740434CT	CT + TT	0.073	0.123	0.020*	1.78(1.09–2.89)	0.403	0.70(0.30–1.63)
rs13264774CT	CT + TT	0.267	0.205	0.057	0.71(0.049–1.01)	0.238	0.69(0.38–1.27)

The table summarizes the univariate and multivariate analyses for the relationships of the gene variants with coronary artery disease, myocardial infarction and congenital heart disease in the studied 4,278 individuals. Bonferroni tests have been performed to adjust for age and sex, and adjustment made for the confounders in the multivariate tests.*p < 0.05; **p < 0.005.

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