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Table 1 An overview of human QGRS conservation across seven orthologous exomes

From: QGRS-Conserve: a computational method for discovering evolutionarily conserved G-quadruplex motifs

Homologous exome

QGRS distribution

Tetrads

2

3

4+

Pan troglodytes (14317)

   

 Entire mRNA

255453 (75%)

16731 (68%)

612 (61%)

 5′-UTR

28398 (65%)

3512 (58%)

165 (53%)

 CDS

170536 (78%)

6887 (75%)

195 (75%)

 3′-UTR

61244 (72%)

6747 (68%)

260 (59%)

Canis lupus familiaris (14513)

   

 Entire mRNA

132440 (36%)

5121 (19%)

144 (13%)

 5′-UTR

6249 (14%)

635 (10%)

25 (7%)

 CDS

121915 (52%)

3744 (38%)

91 (33%)

 3′-UTR

5996 (7%)

858 (8%)

33 (7%)

Mus musculus (15231)

   

 Entire mRNA

156152 (41%)

6461 (23%)

200 (17%)

 5′-UTR

13600 (29%)

1367 (20%)

63 (17%)

 CDS

128755 (52%)

3238 (31%)

75 (25%)

 3′-UTR

16543 (18%)

2010 (18%)

67 (12%)

Danio rerio (10963)

   

 Entire mRNA

29001 (10%)

198 (1%)

(0%)

 5′-UTR

391 (1%)

6 (<1%)

(0%)

 CDS

28580 (16%)

191 (3%)

(0%)

 3′-UTR

188 (<1%)

4 (<1%)

(0%)

Drosophila melanogaster (4407)

   

 Entire mRNA

5970 (6%)

29 (<1%)

(0%)

 5′-UTR

153 (1%)

1 (<1%)

(0%)

 CDS

5798 (9%)

26 (1%)

(0%)

 3′-UTR

42 (<1%)

2 (<1%)

(0%)

Caenorhabditis elegans (3035)

   

 Entire mRNA

1543 (2%)

(0%)

(0%)

 5′-UTR

13 (<1%)

(0%)

(0%)

 CDS

1534 (4%)

(0%)

(0%)

 3′-UTR

5 (<1%)

(0%)

(0%)

Kluyveromyces lactis NRRL Y-1140 (1298)

   

 Entire mRNA

444 (2%)

(0%)

(0%)

 5′-UTR

1 (<1%)

(0%)

(0%)

 CDS

443 (3%)

(0%)

(0%)

 3′-UTR

(0%)

(0%)

(0%)

  1. Human QGRS are conserved in untranslated as well as translated regions of orthologous mRNAs. The conservation is more prevalent in mammalian orthologs. Values in parentheses in the first column represent the number of human mRNAs with an established ortholog in the given species. Values under ‘QGRS distribution’ represent data for QGRS types with two tetrads, three tetrads, or four and higher number of tetrads. For each tetrad column, the first number represents the number of QGRS in H. sapiens mRNA conserved within the given species exome. Data for only QGRS with conservation score ≥0.95 are presented. The second number in parenthesis is the percentage of H. sapiens QGRS conserved in the given species.