Table 4 The cancer-associated processes detected by IVA
Process name | p value | Number of genes associated | Number of variances found | Tumour tissue | Control tissue |
|---|---|---|---|---|---|
CD-SNVs | |||||
Disorder of genitourinary system | 9.05E-14 | 73 | 135 | 1 | 1 |
Cell biology | 4.08E-04 | 69 | 132 | 1 | 1 |
Cell signalling | 3.83E-03 | 25 | 31 | 1 | 1 |
Morphology of body region | 2.55E-03 | 23 | 24 | 1 | 1 |
Abnormal morphology of cells | 1.73E-03 | 18 | 19 | 1 | 1 |
Abnormal morphology of body cavity | 6.17E-04 | 17 | 18 | 1 | 1 |
Morphology of body cavity | 1.36E-03 | 17 | 18 | 1 | 1 |
Morphology of cardiovascular system | 5.80E-04 | 13 | 14 | 1 | 1 |
Abnormal morphology of cardiovascular system | 7.22E-04 | 12 | 13 | 1 | 1 |
Abnormal morphology of thoracic cavity | 1.22E-03 | 11 | 12 | 1 | 1 |
Myelopoiesis of bone marrow | 3.64E-03 | 2: NPM1, RARA | 2 | 1 | 0 |
Quantity of trabecular bone | 4.08E-03 | 2: CREBBP, SMO | 2 | 1 | 0 |
Small indels | |||||
Tissue development | 1.19E-03 | 5 | 5 | 1 | 0 |
Developmental process of tissue | 1.35E-03 | 5 | 5 | 1 | 0 |
Development of organ | 5.05E-03 | 4 | 4 | 1 | 0 |
Organogenesis | 5.32E-03 | 4 | 4 | 1 | 0 |
Colony formation of tumour cell lines | 6.25E-05 | 3 | 3 | 1 | 0 |
Colony formation of cells | 4.44E-04 | 3 | 3 | 1 | 0 |
Colony formation | 5.46E-04 | 3 | 3 | 1 | 0 |
Developmental process of tumour cells | 3.81E-03 | 3 | 3 | 1 | 0 |
Colony formation of carcinoma cell lines | 5.94E-05 | 2 | 2 | 1 | 0 |
Apoptosis of nervous tissue cell lines | 2.49E-04 | 2 | 2 | 1 | 0 |
Outgrowth of bone marrow cells | 7.56E-04 | 1: ALK | 1 | 1 | 0 |
Inflammatory response of bone marrow-derived macrophages | 1.26E-03 | 1: RELA | 1 | 1 | 0 |