Nicotine metabolisms in ancestral and admixed population. Nicotine metabolism was estimated by salivary 3-HC: COT ratio. The X-axis shows population groups with sample size in brackets, and the Y-axis labels the nicotine metabolism. These data provide evidence that a) Maori smokers have significantly (p = 0.001) slower nicotine metabolic rates compared to Caucasian smokers and b) there is a significant linear correlation between nicotine metabolic rate and the degree of Maori ancestry. The admixed population has intermediate nicotine metabolism compared with parental nicotine metabolisms. Reproduced from Lea et al. .