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Table 2 Average patient age, average disease-free survival (DFS), and mutation frequency in breast cancer subtypes with or without mutations

From: Rapid detection of genetic mutations in individual breast cancer patients by next-generation DNA sequencing

Subtype

n (% total)

Average age (years)

Average DFS (months)

Samples with mutations (freq.)

Samples without mutations (freq.)

Average age with mutations (years)

Average age without mutations (months)

P value

Average DFS with mutations (months)

Average DFS without mutations (months)

P value

All

80 (100%)

54.5

38.3

32 (40.0%)

48 (60.0%)

54.9

54.2

0.757

38.8

38.0

0.741

Luminal A

21 (26.3%)

53.7

39.0

9 (42.9%)

12 (57.1%)

53.8

53.7

0.979

40.6

37.8

0.407

Luminal B/HER2−

17 (21.3%)

55.8

39.4

6 (35.3%)

11 (64.7%)

57.3

54.9

0.626

40.5

38.7

0.799

Luminal B/HER2+

24 (30.0%)

52.9

37.3

11 (45.8%)

13 (54.2%)

53.6

52.3

0.772

37.5

37.1

0.936

Triple negative

6 (7.5%)

53.8

37.5

4 (66.7%)

2 (33.3%)

58.8

44.0

0.165

39.8

33.0

0.508

HER2 overexpressing

7 (8.8%)

56.6

34.6

2 (28.6%)

5 (71.4%)

52.5

58.2

0.633

31.5

35.8

0.595

Unknown

5 (6.3%)

59.0

43.0

0 (0.0%)

5 (100%)

-

59.0

-

-

43.0

-