Evaluation of copy number variation and gene expression in neurofibromatosis type-1-associated malignant peripheral nerve sheath tumours

Table 2 The top 20 genes identified as being significantly differentially expressed between MPNSTs and PNFs in the more stringent analysis of 3 vs. 3 samples

Transcript ID	Gene symbol	Ref seq	Mean expression	Mean expression	Fold change	P value	Chromosome	Start	Stop
			Benign	Malignant	Benign vs. malignant	Benign vs. malignant		Start	Stop
2584134	FAP	NM_004460	4.87	8.75	14.75	0.0001	2	163027200	163101589
4013828	NSBP1	NM_030763	5.22	3.67	−2.92	0.0001	X	80211860	80457431
3917555	KRTAP13n4	NM_181600	3.77	3.13	−1.55	0.0001	21	31797943	31809269
3908934	PTGIS	NM_000961	4.58	6.60	4.06	0.0002	20	48120414	48185550
2764192	KIAA0746	NM_015187	4.33	5.82	2.80	0.0002	4	25722248	25865344
2735027	SPP1	NM_001040058	5.65	12.06	85.19	0.0002	4	88408243	88904561
3532353	FAM177A1	NM_001079519	8.01	7.11	−1.86	0.0003	14	35508201	35582327
2779231	ADH1B	NM_000668	6.50	3.18	−9.99	0.0003	4	100226131	100242895
2406926	GRIK3	NM_000831	7.20	3.85	−10.19	0.0004	1	37266614	37524753
3916290	FLJ42200	AK124194	3.32	4.05	1.65	0.0004	21	25353415	25920256
2970942	COL10A1	NM_000493	3.56	4.67	2.17	0.0004	6	116440092	116518549
2450865	CSRP1	NM_004078	9.09	7.28	−3.50	0.0005	1	201445919	201481500
2918982	GRIK2	NM_175768	7.02	3.47	−11.66	0.0005	6	101841683	102690448
3204648	CD72	NM_001782	4.08	5.08	1.99	0.0005	9	35609970	35646790
4006326	EFHC2	NM_025184	4.84	3.42	−2.67	0.0005	X	44006888	44309044
2586845	SLC25A12	NM_003705	5.56	6.30	1.68	0.0006	2	172639117	172750960
2579439	GTDC1	NM_001006636	6.95	5.92	−2.05	0.0006	2	144702190	145123135
3872053	PEG3	NM_006210	5.58	4.17	−2.65	0.0006	19	57285930	57352082
2801526	CCT5	NM_012073	8.62	9.33	1.64	0.0006	5	10250111	10266501
3548152	TDP1	NM_018319	4.17	5.49	2.50	0.0007	14	90421293	90511103

The top 20 genes identified as being significantly differentially expressed between MPNSTs and PNFs in the more stringent analysis of 3 vs. 3 samples.

ISSN: 1479-7364