Skip to main content
Fig. 3 | Human Genomics

Fig. 3

From: SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing

Fig. 3

Measurement of mRNAs for PRC components, KDM2B and DNMTs under conditions of SIRT1 knockdown. Data are for HuVECs (a) and Caco-2 cells (b). SIRT1 knockdown was achieved using two different siRNAs, as indicated. Measurements were by RT-qPCR. Data are mean ± SEM for n = 6–15 relative to the reference genes GAPDH and TOP1 and normalised according to the measurements for the control siRNA. *P < 0.05; **P < 0.01; ***P < 0.001 compared with control by one-way ANOVA then Dunnett’s post hoc test

Back to article page