Table 3 Epigenetic heredity of cancer-causing genes
Cancers | |
|---|---|
Bladder | Aberrant methylation of TWIST, NID2, and RUNX3 |
Brain | Aberrant methylation of RASSF1A and MGMT |
Breast | Aberrant methylation of BRCA1, Sat-2, IGF2, ATM, RASSF1A, and other genes |
Cervix | Hypermethylation of CDKN2A/p16 |
Colon-Rectum | Aberrant methylation of MHL1, SEPT9, IGF2, THBD, C9orf50, and other genes |
Esophagus | Aberrant methylation of CDH1, PIGR, RIN2, and other genes |
Head/Neck | Hypermethylation of CDKN2A/p16 and MGMT |
Kidney | Hypermethylation of TIMP-3 |
Leukemia | Hypermethylation of p15 and chromosomal translocations involving HATs and HMTs |
Liver | Aberrant methylation of multiple genes |
Lung | Hypermethylation of CDKN2A/p16, p73, RARb, RASSF1A, GSTP1, MGMT, and other genes |
Lymphoma/Myeloma | Hypermethylation of DAPK |
Ovary | Hypermethylation of BRCA1 and hypomethylation of SAT2 |
Pancreas | Hypermethylation of APC and hypomethylation of other genes |
Prostate | Hypermethylation of BRCA2 |
Rhabdomyosarcoma | Hypermethylation of PAX3 |
Stomach | Hypomethylation of Cyclin D2 |
Thymus | Hypomethylation of POMC |
Urothelial | Hypomethylation of Satellite DNA |
Uterus | Hypermethylation of hMLH1 leading to Microsatellite instability |